The TNF-receptor-associated factor family - Scaffold molecules for cytokine receptors, kinases and their regulators

被引：314

作者：

Wajant, H ^{[1
]}

Henkler, F ^{[1
]}

Scheurich, P ^{[1
]}

机构：

[1] Univ Stuttgart, Inst Cell Biol & Immunol, D-70569 Stuttgart, Germany

来源：

CELLULAR SIGNALLING | 2001年 / 13卷 / 06期

关键词：

apoptosis; E3-ligase; JNK; NF-kappa B; TNF; TNF-receptor superfamily;

D O I：

10.1016/S0898-6568(01)00160-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The TNF-receptor-associated factor (TRAF) family is a phylogenetically conserved group of scaffold proteins that link receptors of the IL-1R/Toll and TNF receptor family to signalling cascades, leading to the activation of NF-kappaB and mitogen-activated protein kinases. Furthermore, TRAF proteins serve as a docking platform for a variety of regulators of these signalling pathways and are themselves often regulated at the transcriptional and posttranslational level. In this review, we address the structural and molecular basis of TRAF protein functions and highlight their role in cytokine signalling. (C) 2001 Elsevier Science Inc. All rights reserved.

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页码：389 / 400

页数：12

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