Therapeutic exosomal vaccine for enhanced cancer immunotherapy by mediating tumor microenvironment

被引：40

作者：

Lv, Fangfang ^{[1
,2
]}

Liu, Huifang ^{[1
,2
]}

Zhao, Gaoqian ^{[1
,2
]}

Zhao, Erman ^{[1
,2
]}

Yan, Hongyu ^{[2
,3
]}

Che, Ruijun ^{[2
,3
]}

Yang, Xinjian ^{[2
,3
]}

Zhou, Xiaohan ^{[4
]}

Zhang, Jinchao ^{[2
,3
]}

Liang, Xing-Jie ^{[5
]}

Li, Zhenhua ^{[4
]}

机构：

[1] Hebei Univ, Coll Pharmaceut Sci, Inst Life Sci & Green Dev, Key Lab Pharmaceut Qual Control Hebei Prov, Baoding 071002, Peoples R China

[2] Southern Med Univ, Affiliated Dongguan Hosp, Dongguan 523059, Peoples R China

[3] Hebei Univ, Chem Biol Key Lab Hebei Prov, Minist Educ, Key Lab Med Chem & Mol Diag, Baoding 071002, Peoples R China

[4] Hebei Univ, Inst Life Sci & Green Dev, Coll Chem & Environm Sci, Baoding 071002, Peoples R China

[5] Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

来源：

ISCIENCE | 2022年 / 25卷 / 01期

基金：

中国国家自然科学基金;

关键词：

NANOPARTICLES PROMOTE; MACROPHAGES; POLARIZATION; TAMS;

D O I：

10.1016/j.isci.2021.103639

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Tumor immunotherapy has been convincingly demonstrated as a feasible approach for treating cancers. Although promising, the immunosuppressive tumor microenvironment (TME) has been recognized as a major obstacle in tumor immunotherapy. It is highly desirable to release an immunosuppressive "brake'' for improving cancer immunotherapy. Among tumor-infiltrated immune cells, tumor-associated macrophages (TAMs) play an important role in the growth, invasion, and metastasis of tumors. The polarization of TAMs (M2) into the M1 type can alleviate the immunosuppression of the TME and enhance the effect of immunotherapy. Inspired by this, we constructed a therapeutic exosomal vaccine from antigen-stimulated M1-type macrophages (M1(OVA)-Exos). M1(OVA)-Exos are capable of polarizing TAMs into M1 type through downregulation of the Wnt signaling pathway. Mediating the TME further activates the immune response and inhibits tumor growth and metastasis via the exosomal vaccine. Our study provides a new strategy for the polarization of TAMs, which augments cancer vaccine therapy efficacy.

引用

页数：19

共 38 条

[1]

Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype [J].