Evidence of a TH1-shift of local vaginal inflammatory response during bacterial vaginosis

被引：23

作者：

Anton, G. ^{[2
]}

Rid, J. ^{[2
]}

Mylonas, I. ^{[1
]}

Friese, K. ^{[1
,2
]}

Weissenbacher, E. -R. ^{[2
]}

机构：

[1] Univ Munich, Klinikum Innenstadt, Dept Obstet & Gynecol 1, D-8000 Munich, Germany

[2] Univ Munich, Klinikum Innenstadt, Dept Obstet & Gynecol, D-8000 Munich, Germany

来源：

INFECTION | 2008年 / 36卷 / 02期

关键词：

D O I：

10.1007/s15010-007-7152-2

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objective: To determine the levels of pro-inflammatory and anti-inflammatory cytokines in the vagina of healthy women and in bacterial vaginosis (BV) patients. Methods: Interleukin (IL)-1 alpha, 1 beta, 5 and 10 were analyzed by ELISA in vaginal wash fluids from 50 non-pregnant patients with BV and 112 healthy women. Results: Levels of IL-1 beta were higher and those of IL-10 lower in BV-patients than in healthy women. There was a tendency towards higher levels of IL-1 alpha in BV patients, but these data were not statistically significant. Conclusion: We found evidence for a shift towards a TH1-dominated vaginal cytokine profile in the pathogenesis of BV. Levels of a TH1-cytokine were elevated and those of a TH2-cytokine lowered in BV-patients as compared to healthy controls. This points to a vaginal TH1-response during BV and to the importance of cell-mediated immunity in local vaginal infections.

引用

页码：147 / 152

页数：6

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