Molecular properties of the PTH/PTHrP receptor

被引:123
作者
Gardella, TJ [1 ]
Jüppner, H
机构
[1] Massachusetts Gen Hosp, Endocrine Unit, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Dept Pediat, Boston, MA 02114 USA
[3] Harvard Univ, Sch Med, Boston, MA 02114 USA
关键词
D O I
10.1016/S1043-2760(01)00409-X
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The receptor for parathyroid hormone (PTH) and PTH-related protein (PTHrP) is a G protein-coupled receptor (GPCR) that plays a key role in controlling blood Ca2+ concentration and endochondral bone formation. This review focuses on the molecular mechanisms by which the receptor recognizes the PTH and PTHrP peptide ligands and transmits their signal across the cell membrane. The available data suggest that there are two principal components to the ligand-receptor interaction. First, a docking interaction between the C-terminal portion of PTH(1-34) and the N-terminal extracellular domain of the receptor; and second, a weaker interaction between the N-terminal portion of the ligand and the juxtamembrane region of the receptor, which induces signal transduction. A full understanding of these processes could lead to new PTH/PTHrP receptor ligands that are effective in controlling diseases of bone and mineral metabolism, such as osteoporosis.
引用
收藏
页码:210 / 217
页数:8
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