Guilty until proven innocent: the case of NPC1 and cholesterol

被引：27

作者：

Ioannou, YA ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Human Genet, New York, NY 10029 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2005年 / 30卷 / 09期

关键词：

D O I：

10.1016/j.tibs.2005.07.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cholesterol accumulation in the endosomes and lysosomes of Niemann-Pick C (NPC) cells is considered to be the hallmark of this disorder, so the main focus of NPC research has revolved around cholesterol and its role in disease pathogenesis. However, recent data indicate that cholesterol is not the primary culprit in this human lipidosis. I propose a new hypothesis for the potential action or function of the NPC1 protein in the endosome. In this context, the relationship of NPC2 and NPC1 is also discussed.

引用

页码：498 / 505

页数：8

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