HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication

被引：139

作者：

Nicot, C

Dundr, M

Johnson, JM

Fullen, JR

Alonzo, N

Fukumoto, R

Princler, GL

Derse, D

Misteli, T

Franchini, G

机构：

[1] NCI, Anim Models & Retroviral Vaccines Sect, Bethesda, MD 20892 USA

[2] NCI, Lab Receptor Biol & Gene Express, Bethesda, MD 20892 USA

[3] NCI, Basic Res Lab, Ctr Canc Res, Ft Detrick, MD 21702 USA

来源：

NATURE MEDICINE | 2004年 / 10卷 / 02期

关键词：

D O I：

10.1038/nm984

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) persists despite a vigorous virus-specific host immune response, and causes adult T-cell leukemia and lymphoma in approximately 2% of infected individuals. Here we report that HTLV-1 has evolved a genetic function to restrict its own replication by a novel post-transcriptional mechanism. The HTLV-1-encoded p30(II) is a nuclear-resident protein that binds to, and retains in the nucleus, the doubly spliced mRNA encoding the Tax and Rex proteins. Because Tex and Rex are positive regulators of viral gene expression(1,2), their inhibition by p30(II) reduces virion production. p30(II) inhibits virus expression by reducing Tax and Rex protein expression.

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页码：197 / 201

页数：5

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