Death receptor signalling in central nervous system inflammation and demyelination

被引：51

作者：

Mc Guire, Conor ^{[1
,2
]}

Beyaert, Rudi ^{[1
,2
]}

van Loo, Geert ^{[1
,2
]}

机构：

[1] VIB, Unit Mol Signal Transduct Inflammat, Dept Mol Biomed Res, B-9052 Ghent, Belgium

[2] Univ Ghent, Dept Biomed Mol Biol, B-9052 Ghent, Belgium

来源：

TRENDS IN NEUROSCIENCES | 2011年 / 34卷 / 12期

关键词：

EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; TUMOR-NECROSIS-FACTOR; APOPTOSIS-INDUCING LIGAND; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; NF-KAPPA-B; AFFINITY NEUROTROPHIN RECEPTOR; PROGRAMMED CELL-DEATH; MULTIPLE-SCLEROSIS PATIENTS; REGULATORY T-CELLS; FAS LIGAND;

D O I：

10.1016/j.tins.2011.09.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Death receptors (DRs) are members of the tumor necrosis factor receptor (TNF-R) superfamily that are characterised by the presence of a conserved intracellular death domain and are able to trigger a signalling pathway leading to apoptosis. Strong evidence suggests that DRs contribute to the pathology of tissue destructive diseases, including multiple sclerosis (MS), the most common inflammatory demyelinating disease of the central nervous system (CNS). Here, we review the evidence supporting a role for DRs in MS pathology and its implications for the development of therapeutic strategies for MS and other demyelinating pathologies of the CNS.

引用

页码：619 / 628

页数：10

共 115 条

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