Failure to eradicate AIDS-associated primary effusion lymphoma with high-dose chemotherapy and autologous stem cell reinfusion: Case report and literature review

被引：39

作者：

Waddington, TW ^{[1
]}

Aboulafia, DM ^{[1
]}

机构：

[1] Virginia Mason Med Ctr, Hematol Oncol Sect, Seattle, WA 98111 USA

来源：

AIDS PATIENT CARE AND STDS | 2004年 / 18卷 / 02期

关键词：

D O I：

10.1089/108729104322802498

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Primary effusion lymphoma (PEL), also known as body cavity-based lymphoma, is a newly recognized AIDS-related malignancy that is etiopathologically linked to Kaposi's sarcoma (KS)-associated human herpes virus type 8 (HHV-8). PEL is characterized by presentation in serous body cavities without identifiable tumor masses. Tumor cells have high-grade morphologic features, an indeterminate immunophenotype, B-lineage genotype, and contain HHV-8 and often Epstein-Barr virus. PEL rarely responds to systemic chemotherapy. Herein, we describe what we believe is the first patient with AIDS-associated PEL to be treated with high-dose chemotherapy and autologous stem cell reinfusion. Treatment was well tolerated but the patient succumbed to progressive cancer. Our experience with this patient serves to underscore the high mortality rate associated with this unique neoplasm.

引用

页码：67 / 73

页数：7

共 41 条

[1]

Appleby P, 2000, JNCI-J NATL CANCER I, V92, P1823, DOI 10.1093/jnci/92.22.1823

[2]

Ascoli V, 2001, J PATHOL, V193, P200

[3]

Banks P.M., 2001, Pathology and genetics of tumour of haematopoietic and lymphoid tissues, P179

[4] Primary pulmonary AIDS-related lymphoma - Radiographic and CT findings [J].

Bazot, M ;

Cadranel, J ;

Benayoun, S ;

Tassart, M ;

Bigot, JM ;

Carette, MF .

CHEST, 1999, 116 (05) :1282-1286

[5]

BERRYMAN RB, 2000, 42 ANN AM SOC HEM M

[6] Changes in AIDS-related lymphoma since the era of highly active antiretroviral therapy [J].

Besson, C ;

Goubar, A ;

Gabarre, J ;

Rozenbaum, W ;

Pialoux, G ;

Châtelet, FP ;

Katlama, C ;

Charlotte, F ;

Dupont, B ;

Brousse, N ;

Huerre, M ;

Mikol, J ;

Camparo, P ;

Mokhtari, K ;

Tulliez, M ;

Salmon-Céron, D ;

Boué, F ;

Costagliola, D ;

Raphaël, M .

BLOOD, 2001, 98 (08) :2339-2344

[7]

BOULANGER E, 2000, 42 ANN AM SOC HEM M

[8]

BURGER R, 2000, 42 ANN AM SOC HEM M

[9]

Cannon M, 2000, SEMIN ONCOL, V27, P409

[10] The role of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in lymphoproliferative diseases [J].

Cesarman, E ;

Knowles, DM .

SEMINARS IN CANCER BIOLOGY, 1999, 9 (03) :165-174

← 1 2 3 4 5 →