Antisense pharmacodynamics: Critical issues in the transport and delivery of antisense oligonucleotides

被引：128

作者：

Juliano, RL ^{[1
]}

Alahari, S

Yoo, H

Kole, R

Cho, M

机构：

[1] Univ N Carolina, Dept Pharmacol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Canc Ctr, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Sch Pharm, Chapel Hill, NC 27599 USA

来源：

PHARMACEUTICAL RESEARCH | 1999年 / 16卷 / 04期

关键词：

antisense; oligonucleotides; drug delivery; pharmacodynamics; biodistribution;

D O I：

10.1023/A:1011958726518

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

dThis review critically examines current understanding of the kinetics and biodistribution of antisense oligonucleotides, both at the cellular level and at the level of the intact organism. The pharmacodynamic relationships between biodistribution and the ultimate biological effects of antisense agents are considered. The problems and advantages inherent in the use of delivery systems are discussed in the light of further enhancing in vivo pharmacological actions of oligonucleotides.

引用

页码：494 / 502

页数：9

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