Photostability and phototoxicity studies on diltiazem

被引：19

作者：

Andrisano, V

Hrelia, P

Gotti, R

Leoni, A

Cavrini, V

机构：

[1] Univ Bologna, Dipartimento Sci Farmaceut, I-40126 Bologna, Italy

[2] Univ Bologna, Dipartimento Farmacol, I-40126 Bologna, Italy

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2001年 / 25卷 / 3-4期

关键词：

diltiazem; photodegradation; photostability; hydrolysis; HPLC analysis; mutagenicity; photoxicity;

D O I：

10.1016/S0731-7085(00)00588-4

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The photostability of diltiazem was studied in aqueous solutions at different pH values. Firstly, the hydrolysis of the drug to desacetyldiltiazem in alkaline medium was evaluated and then the drug photodegradation under exposure to UVA-UVB radiation (solar simulator) was monitored by HPLC methods. The main photoproduct was isolated and characterized as diltiazem-S-oxide on the basis of the NMR and mass spectra. The HPLC method was also applied to the selective analysis of diltiazem in commercial formulations. Tests on mutagenicity and photomutagenicity of the drug were also carried out using Salmonella typhimurium TA 102 strain. In this testing the drug neither was mutagenic nor toxic. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：589 / 597

页数：9

共 20 条

[1] COMPARISON OF SOLID-PHASE EXTRACTION AND LIQUID-LIQUID-EXTRACTION METHODS FOR LIQUID-CHROMATOGRAPHIC DETERMINATION OF DILTIAZEM AND ITS METABOLITES IN PLASMA [J].