Role of natural and immune IgM antibodies in immune responses

被引：430

作者：

Boes, M ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

MOLECULAR IMMUNOLOGY | 2000年 / 37卷 / 18期

关键词：

autoimmunity; bacterial infection; complement; immune response; immunoglobulin M; viral infection;

D O I：

10.1016/S0161-5890(01)00025-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IgM antibodies constitute the major component of the natural antibodies and is also the first class of antibodies produced during a primary antibody response. The IgM-type antibodies differ from other classes of antibodies in that they are predominantly produced by B1 cells, in the absence of apparent stimulation by specific antigens. In addition, IgM antibodies are mostly encoded by germline V gene segments and have low affinities but broad specificites to both foreign and self structures. New developments regarding the function of both immune IgM antibodies and natural IgM antibodies will be examined here. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1141 / 1149

页数：9

共 81 条

[1] STRUCTURE AND FUNCTION OF THE COMPLEMENT RECEPTORS, CR-1 (CD35) AND CR-2 (CD21) [J].

AHEARN, JM ;

FEARON, DT .

ADVANCES IN IMMUNOLOGY, 1989, 46 :183-219

[2] Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen [J].

Ahearn, JM ;

Fischer, MB ;

Croix, D ;

Goerg, S ;

Ma, MH ;

Xia, JR ;

Zhou, XN ;

Howard, RG ;

Rothstein, TL ;

Carroll, MC .

IMMUNITY, 1996, 4 (03) :251-262

[3] Antibody production in mice deficient for complement receptors 1 and 2 can be induced by IgG/Ag and IgE/Ag, but not IgM/Ag complexes [J].

Applequist, SE ;

Dahlström, J ;

Jiang, N ;

Molina, H ;

Heyman, B .

JOURNAL OF IMMUNOLOGY, 2000, 165 (05) :2398-2403

[4]

AVRAMEAS S, 1991, IMMUNOL TODAY, V12, P154

[5] THE ACUTE-PHASE RESPONSE [J].

BAUMANN, H ;

GAULDIE, J .

IMMUNOLOGY TODAY, 1994, 15 (02) :74-80

[6] B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection [J].

Baumgarth, N ;

Herman, OC ;

Jager, GC ;

Brown, LE ;

Herzenberg, LA ;

Chen, JZ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (02) :271-280

[7] Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM [J].

Boes, M ;

Schmidt, T ;

Linkemann, K ;

Beaudette, BC ;

Marshak-Rothstein, A ;

Chen, JZ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (03) :1184-1189

[8] A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection [J].

Boes, M ;

Prodeus, AP ;

Schmidt, T ;

Carroll, MC ;

Chen, JZ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (12) :2381-2386

[9]

Boes M, 1998, J IMMUNOL, V160, P4776

[10] Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies [J].

Botto, M ;

Dell'Agnola, C ;

Bygrave, AE ;

Thompson, EM ;

Cook, HT ;

Petry, F ;

Loos, M ;

Pandolfi, PP ;

Walport, MJ .

NATURE GENETICS, 1998, 19 (01) :56-59

← 1 2 3 4 5 6 7 8 9 →