Plasmodium telomeres:: a pathogen's perspective

被引：92

作者：

Scherf, A ^{[1
]}

Figueiredo, LM ^{[1
]}

Freitas-Junior, LH ^{[1
]}

机构：

[1] Inst Pasteur, CNRS URA 1960, Unite Biol Interact Hote Parasite, F-75724 Paris 15, France

来源：

CURRENT OPINION IN MICROBIOLOGY | 2001年 / 4卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

D O I：

10.1016/S1369-5274(00)00227-7

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

New data on the organization of plasmodial telomeres has recently become available. Telomeres form clusters of four to seven heterologous chromosome ends at the nuclear periphery in asexual and sexual parasite stages. This subnuclear compartment promotes gene conversion between members of subtelomeric virulence factor genes in heterologous chromosomes resulting in diversity of antigenic and adhesive phenotypes. This has important implications for parasite survival.

引用

页码：409 / 414

页数：6

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