New pathogenic paradigms in inflammatory bowel disease

被引：118

作者：

Di Sabatino, Antonio ^{[1
]}

Biancheri, Paolo ^{[2
]}

Rovedatti, Laura

MacDonald, Thomas T. ^{[2
]}

Corazza, Gino R.

机构：

[1] Univ Pavia, Med Clin 1, Fdn IRCCS Policlin S Matteo,Dept Med 1, Ctr Studio & Cura Malattie Infiammatorie Croniche, I-27100 Pavia, Italy

[2] Barts & London Queen Marys Sch Med & Dent, Blizard Inst Cell & Mol Sci, Ctr Immunol & Infect Dis, London, England

来源：

INFLAMMATORY BOWEL DISEASES | 2012年 / 18卷 / 02期

关键词：

Crohn's disease; cytokines; mucosal immunology; T cell; ulcerative colitis; GENOME-WIDE ASSOCIATION; CROHNS-DISEASE; DENDRITIC CELLS; TH17; CELLS; HOMEOSTASIS; IMMUNITY; GENE; AUTOPHAGY; ATG16L1; BETA;

D O I：

10.1002/ibd.21735

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Recent progresses in basic science have opened new pathogenic scenarios in inflammatory bowel disease. The T helper cell type (Th)1/Th2 paradigm has been outdated thanks to the advances in understanding the function of Th17 cells. Innate immunity, nonimmune cells, and defective tolerogenic mechanisms play a no less crucial role than do adaptive immunity, immune cells, and hyperactivation of effector mechanisms. These new paradigms, together with the no longer static but dynamic vision of intestinal inflammation, highlight new possible therapeutic targets in inflammatory bowel disease. (Inflamm Bowel Dis 2011;)

引用

页码：368 / 371

页数：4

共 30 条

[1]

Functional consequences of NOD2 (CARD15) mutations [J].

Abraham, Clara ;

Cho, Judy H. .

INFLAMMATORY BOWEL DISEASES, 2006, 12 (07) :641-650

[2]

Phenotypic and functional features of human Th17 cells [J].

Annunziato, Francesco ;

Cosmi, Lorenzo ;

Santarlasci, Veronica ;

Maggi, Laura ;

Liotta, Francesco ;

Mazzinghi, Benedetta ;

Parente, Eliana ;

Fili, Lucia ;

Ferri, Simona ;

Frosali, Francesca ;

Giudici, Francesco ;

Romagnani, Paola ;

Parronchi, Paola ;

Tonelli, Francesco ;

Maggi, Enrico ;

Romagnani, Sergio .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1849-1861

[3]

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells [J].

Cadwell, Ken ;

Liu, John Y. ;

Brown, Sarah L. ;

Miyoshi, Hiroyuki ;

Loh, Joy ;

Lennerz, Jochen K. ;

Kishi, Chieko ;

Kc, Wumesh ;

Carrero, Javier A. ;

Hunt, Steven ;

Stone, Christian D. ;

Brunt, Elizabeth M. ;

Xavier, Ramnik J. ;

Sleckman, Barry P. ;

Li, Ellen ;

Mizushima, Noboru ;

Stappenbeck, Thaddeus S. ;

Virgin, Herbert W. .

NATURE, 2008, 456 (7219) :259-U62

[4]

Interleukin-25 Inhibits Interleukin-12 Production and Th1 Cell-Driven Inflammation in the Gut [J].

Caruso, Roberta ;

Sarra, Massimiliano ;

Stolfi, Carmine ;

Rio, Angelamaria ;

Fina, Daniele ;

Fantini, Massimo Claudio ;

Pallone, Francesco ;

MacDonald, Thomas T. ;

Monteleone, Giovanni .

GASTROENTEROLOGY, 2009, 136 (07) :2270-2279

[5]

Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients [J].

Danese, S ;

de la Motte, C ;

Sturm, A ;

Vogel, JD ;

West, GA ;

Strong, SA ;

Katz, JA ;

Fiocchi, C .

GASTROENTEROLOGY, 2003, 124 (05) :1249-1264

[6]

Increased enterocyte apoptosis in inflamed areas of Crohn's disease [J].

Di Sabatino, A ;

Ciccocioppo, R ;

Luinetti, O ;

Ricevuti, L ;

Morera, R ;

Cifone, AG ;

Solcia, E ;

Corazza, GR .

DISEASES OF THE COLON & RECTUM, 2003, 46 (11) :1498-1507

[7]

Transforming growth factor β signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures [J].

Di Sabatino, A. ;

Jackson, C. L. ;

Pickard, K. M. ;

Buckley, M. ;

Rovedatti, L. ;

Leakey, N. A. B. ;

Picariello, L. ;

Cazzola, P. ;

Monteleone, G. ;

Tonelli, F. ;

Corazza, G. R. ;

MacDonald, T. T. ;

Pender, S. L. .

GUT, 2009, 58 (06) :777-789

[8]

IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease [J].

Dubinsky, Marla C. ;

Wang, Dai ;

Picornell, Yoana ;

Wrobel, Iwona ;

Katzir, Lirono ;

Quiros, Antonio ;

Dutridge, Debra ;

Wahbeh, Ghassan ;

Silber, Gary ;

Bahar, Ron ;

Mengesha, Emebet ;

Targan, Stephan R. ;

Taylor, Kent D. ;

Rotter, Jerome I. .

INFLAMMATORY BOWEL DISEASES, 2007, 13 (05) :511-515

[9]

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene [J].

Duerr, Richard H. ;

Taylor, Kent D. ;

Brant, Steven R. ;

Rioux, John D. ;

Silverberg, Mark S. ;

Daly, Mark J. ;

Steinhart, A. Hillary ;

Abraham, Clara ;

Regueiro, Miguel ;

Griffiths, Anne ;

Dassopoulos, Themistocles ;

Bitton, Alain ;

Yang, Huiying ;

Targan, Stephan ;

Datta, Lisa Wu ;

Kistner, Emily O. ;

Schumm, L. Philip ;

Lee, Annette T. ;

Gregersen, Peter K. ;

Barmada, M. Michael ;

Rotter, Jerome I. ;

Nicolae, Dan L. ;

Cho, Judy H. .

SCIENCE, 2006, 314 (5804) :1461-1463

[10]

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1 [J].

Hampe, Jochen ;

Franke, Andre ;

Rosenstiel, Philip ;

Till, Andreas ;

Teuber, Markus ;

Huse, Klaus ;

Albrecht, Mario ;

Mayr, Gabriele ;

De La Vega, Francisco M. ;

Briggs, Jason ;

Guenther, Simone ;

Prescott, Natalie J. ;

Onnie, Clive M. ;

Haesler, Robert ;

Sipos, Bence ;

Foelsch, Ulrich R. ;

Lengauer, Thomas ;

Platzer, Matthias ;

Mathew, Christopher G. ;

Krawczak, Michael ;

Schreiber, Stefan .

NATURE GENETICS, 2007, 39 (02) :207-211

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