In Silico Inspired Total Synthesis of (-)-Dolabriferol

被引：14

作者：

Currie, Russell H. ^{[1
]}

Goodman, Jonathan M. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Unilever Ctr Mol Sci Informat, Cambridge CB2 8PH, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 19期

基金：

英国工程与自然科学研究理事会;

关键词：

aldol reaction; asymmetric synthesis; biomimetic synthesis; natural products; polyketides; LACTATE-DERIVED KETONES; ANTI-ALDOL REACTIONS; PI-FACE SELECTIVITY; ENANTIOSELECTIVE SYNTHESIS; POLYPROPIONATE SYNTHESIS; DOLABRIFEROL; REDUCTION; PROGRAM; MOIETY; ROBIA;

D O I：

10.1002/anie.201109080

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Going retro: The diazabicycloundecane-induced retro-Claisen rearrangement of a linear precursor serves as the key step to form the hindered ester of the polypropionate dolabriferol (1, see scheme, PMB=p-methoxybenzyl, PMP=p-methoxyphenyl, TES=triethylsilyl). The rearrangement is thought to mimic the biosynthetic formation of 1. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4695 / 4697

页数：3

共 21 条

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