Straightforward access to simplified sphingosine-1-phosphate analogues

被引：6

作者：

Grijalvo, Santiago

机构：

[1] CSIC, CID, Dept Organ & Biol Chem, RUBAM, ES-08034 Barcelona, Spain

[2] Univ Barcelona, Unit Pharmaceut chem, Fac Pharm, E-08007 Barcelona, Spain

[3] CSIC, Dept Organ & Biol Chem, IIQAB, RUBAM, ES-08034 Barcelona, Spain

[4] Univ Barcelona, Unit Pharmaceut Chem, Fac Pharm, Barcelona 7, Spain

来源：

SYNTHETIC COMMUNICATIONS | 2007年 / 37卷 / 16期

关键词：

amino phosphate; combinatorial; phosphorylation; sphingolipids;

D O I：

10.1080/00397910701466030

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A straightforward approach for the synthesis of a new series of amino phosphates structurally related to sphingosine-1-phosphate is described. The commercial availability of the required starting building blocks, the reduced number of steps, and the ease of purification of the intermediate and final compounds make the approach amenable to combinatorial protocols.

引用

收藏

页码：2737 / 2751

页数：15

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