Bromobalhimycin and chlorobromobalhimycins -: Illuminating the potential of halogenases in glycopeptide antibiotic biosyntheses

被引：59

作者：

Bister, B

Bischoff, D

Nicholson, GJ

Stockert, S

Wink, J

Brunati, C

Donadio, S

Pelzer, S

Wohlleben, W

Süssmuth, RD

机构：

[1] Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany

[2] Univ Tubingen, Lehrstuhl Mikrobiol Biotechnol, D-72076 Tubingen, Germany

[3] Biosearch Italia, I-21040 Gerenzano, VA, Italy

[4] Aventis Pharma Deutschland GmbH, Res Scientist Nat Prod, D-65926 Frankfurt, Germany

来源：

CHEMBIOCHEM | 2003年 / 4卷 / 07期

关键词：

antibiotics; balhimycin; bromine; glycopeptides; halgoenase;

D O I：

10.1002/cbic.200300619

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Can bromine beat bacteria? By varying the amounts of chloride and bromide salts in fermentation culture media, we have generated novel sets of vancomycin-type glycopeptides with bromine substution. This study extends the sequence of substituents at the aglycon moiety of balhimycin from H through F and Cl to Br (see scheme) and opens up possibilities for the investigation of substituent effects upon the activity of glycopeptide antibiotics.

引用

页码：658 / 662

页数：5

共 37 条

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