Deciphering cryptic similarities in protein binding sites

被引：17

作者：

Kauvar, LM ^{[1
]}

Villar, HO ^{[1
]}

机构：

[1] Terrapin Technol Inc, S San Francisco, CA 94080 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1998年 / 9卷 / 04期

关键词：

D O I：

10.1016/S0958-1669(98)80013-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Rapid expansion in the number of plausible drug targets arising from genomics research has created new pressures for increased efficiency in discovery of high specificity candidate drug compunds. Improved understanding of conserved features among protein structures provides a promising route to achieving this goal. Indirect evidence implies that important similarities are now ripe for elucidation by emerging experimental approaches.

引用

收藏

页码：390 / 394

页数：5

相关论文

共 49 条

[1] THE MODE OF ACTION OF ASPIRIN-LIKE DRUGS - EFFECT ON INDUCIBLE NITRIC-OXIDE SYNTHASE [J].

AMIN, AR ;

VYAS, P ;

ATTUR, M ;

LESZCZYNSKAPIZIAK, J ;

PATEL, IR ;

WEISSMANN, G ;

ABRAMSON, SB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (17) :7926-7930

[2] COMPUTER-AIDED MOLECULAR MODELING OF THE BINDING-SITE ARCHITECTURE FOR 8 MONOCLONAL-ANTIBODIES THAT BIND A HIGH POTENCY GUANIDINIUM SWEETENER [J].

ANCHIN, JM ;

MANDAL, C ;

CULBERSON, C ;

SUBRAMANIAM, S ;

LINTHICUM, DS .

JOURNAL OF MOLECULAR GRAPHICS, 1994, 12 (04) :257-266

[3] The properties of known drugs .1. Molecular frameworks [J].

Bemis, GW ;

Murcko, MA .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (15) :2887-2893

[4] SELECTIVE-INHIBITION OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-1 (CYCLOOXYGENASE-1) BY VALERYLSALICYLIC ACID [J].

BHATTACHARYYA, DK ;

LECOMTE, M ;

DUNN, J ;

MORGANS, DJ ;

SMITH, WL .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1995, 317 (01) :19-24

[5] Small molecule-dependent genetic selection in stochastic nanodroplets as a means of detecting protein-ligand interactions on a large scale [J].

Borchardt, A ;

Liberles, SD ;

Biggar, SR ;

Crabtree, GR ;

Schreiber, SL .

CHEMISTRY & BIOLOGY, 1997, 4 (12) :961-968

[6]

BOWIE JU, 1996, Patent No. 5585277

[7] Molecular similarity based on DOCK-generated fingerprints [J].

Briem, H ;

Kuntz, ID .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (17) :3401-3408

[8] Use of structure Activity data to compare structure-based clustering methods and descriptors for use in compound selection [J].

Brown, RD ;

Martin, YC .

JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 1996, 36 (03) :572-584

[9] NOVEL PROCEDURE FOR STRUCTURE REFINEMENT IN HOMOLOGY MODELING AND ITS APPLICATION TO THE HUMAN CLASS MU-GLUTATHIONE S-TRANSFERASES [J].

CACHAU, RE ;

ERICKSON, JW ;

VILLAR, HO .

PROTEIN ENGINEERING, 1994, 7 (07) :831-839

[10] Hormone-sensitive lipase is structurally related to acetylcholinesterase, bile salt-stimulated lipase, and several fungal lipases - Building of a three-dimensional model for the catalytic domain of hormone-sensitive lipase [J].

Contreras, JA ;

Karlsson, M ;

Osterlund, T ;

Laurell, H ;

Svensson, A ;

Holm, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (49) :31426-31430

← 1 2 3 4 5 →