Detection of HLA-A*24 null alleles by DNA typing methods

被引：11

作者：

Williams, F

Curran, MD

Middleton, D

机构：

[1] City Hosp, No Ireland Reg Histocompatibil & Immunogenet Lab, Belfast BT9 7TS, Antrim, North Ireland

[2] Queens Univ Belfast, Belfast, Antrim, North Ireland

[3] Univ Ulster, Coleraine BT52 1SA, Londonderry, North Ireland

来源：

TISSUE ANTIGENS | 1998年 / 52卷 / 03期

关键词：

HLA-A*24; non-expression;

D O I：

10.1111/j.1399-0039.1998.tb03034.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A number of cases have been identified (seven unrelated individuals from the Northern Ireland bone marrow donor registry and two family groups) where an HLA-A*24 allele fails to express the normal HLA-A24 antigen. Family information has revealed common haplotypes with respect to each non-expressed allele indicating that the occurrence of these mutations has been a recent event. Two methods for the clinical typing of these alleles have been evaluated - PCR-SSOP and PCR-SSCP analysis.

引用

页码：208 / 212

页数：5

共 18 条

[1]

*ASHI, 1997, HLA CLASS 1 NUCL AL

[2]

Blasczyk R., 1998, European Journal of Immunogenetics, V25, P7

[3] Nucleotide sequences of MHC class I introns 1, 2, and 3 in humans and intron 2 in nonhuman primates [J].

Cereb, N ;

Kong, Y ;

Lee, S ;

Maye, P ;

Yang, SY .

TISSUE ANTIGENS, 1996, 47 (06) :498-511

[4]

CURRAN MD, 1998, EUR J IMMUNOGENET, V25, P49

[5]

ISHIKAWA Y, 1995, IMMUNOGENETICS, V43, P1

[6] GENETIC DIVERSITY IN THE NONSTRUCTURAL GENE OF PARVOVIRUS B19 DETECTED BY SINGLE-STRANDED CONFORMATIONAL POLYMORPHISM ASSAY (SSCP) AND PARTIAL NUCLEOTIDE SEQUENCING [J].

KERR, JR ;

CURRAN, MD ;

MOORE, JE ;

ERDMAN, DD ;

COYLE, PV ;

NUNOUE, T ;

MIDDLETON, D ;

FERGUSON, WP .

JOURNAL OF VIROLOGICAL METHODS, 1995, 53 (2-3) :213-222

[7]

KERR JR, 1996, CLIN MOL PATHOL, V49, P315

[8] A nucleotide insertion in exon 4 is responsible for the absence of expression of an HLA-A*01 allele [J].

Laforet, M ;

Froelich, N ;

Parissiadis, A ;

Pfeiffer, B ;

Schell, A ;

Faller, B ;

WoehlJaegle, ML ;

Cazenave, JP ;

Tongio, MM .

TISSUE ANTIGENS, 1997, 50 (04) :347-350

[9] An intronic mutation responsible for a low level of expression of an HLA-A*24 allele [J].

Laforet, M ;

Froelich, N ;

Parissiadis, A ;

Bausinger, H ;

Pfeiffer, B ;

Tongio, MM .

TISSUE ANTIGENS, 1997, 50 (04) :340-346

[10] Stable inheritance of an HLA-''blank'' phenotype associated with a structural mutation in the HLA-A*0301 gene [J].

Lienert, K ;

Russ, G ;

Lester, S ;

Bennett, G ;

Gao, X ;

McCluskey, J .

TISSUE ANTIGENS, 1996, 48 (03) :187-191

← 1 2 →