Growth factor protection against cytokine-induced apoptosis in neonatal rat islets of Langerhans: role of Fas

被引：42

作者：

Harrrison, M ^{[1
]}

Dunger, AM

Berg, S

Mabley, J

John, N

Green, MHL

Green, IC

机构：

[1] Univ Sussex, Sch Biol Sci, Dept Biochem, Brighton BN1 9QG, E Sussex, England

[2] Cent Inst Diabet Gerhardt Katsch, D-2201 Karlsburg, Germany

[3] Univ Sussex, MRC, Cell Mutat Unit, Brighton BN1 9RR, E Sussex, England

[4] Univ Brighton, Sch Pharm & Biomol Sci, Brighton BN2 4GJ, E Sussex, England

来源：

FEBS LETTERS | 1998年 / 435卷 / 2-3期

基金：

澳大利亚研究理事会;

关键词：

growth factor; cytokine; Fas; apoptosis; islet of Langerhans;

D O I：

10.1016/S0014-5793(98)01051-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Treatment of neonatal rat islets of Langerhans with combined cytokines (interleukin-1 beta 10(-10) M, tumour necrosis factor-alpha 10(-10) M, interferon-gamma 5 U/ml) led to extensive cell death, which was potentiated by Fas activation with the anti-Fas cytolytic antibody JO2, Pre-treatment with insulin (25 ng/ml) or insulin-like growth factor-1 (10(-8) M) gave only partial protection against cell killing, but prevented the Fas-mediated component, In the absence of cytokine treatment, Fas-mediated killing was not observed. (C) 1998 Federation of European Biochemical Societies.

引用

页码：207 / 210

页数：4

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