Molecular imaging: Looking at problems, seeing solutions

被引：314

作者：

Herschman, HR

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Biol Chem, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol Med Pharmacol, Los Angeles, CA 90095 USA

来源：

SCIENCE | 2003年 / 302卷 / 5645期

关键词：

D O I：

10.1126/science.1090585

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Noninvasive molecular-imaging technologies are providing researchers with exciting new opportunities to study small-animal models of human disease. With continued improvements in instrumentation, identification of better imaging targets by genome-based approaches, and design of better imaging probes by innovative chemistry, these technologies promise to play increasingly important roles in disease diagnosis and therapy.

引用

收藏

页码：605 / 608

页数：4

相关论文

共 23 条

[1] Visualization of advanced human prostate cancer lesions in living mice by a targeted gene transfer vector and optical imaging [J].

Adams, JY ;

Johnson, M ;

Sato, M ;

Berger, F ;

Gambhir, SS ;

Carey, M ;

Iruela-Arispe, ML ;

Wu, L .

NATURE MEDICINE, 2002, 8 (08) :891-896

[2] Molecular-genetic imaging: current and future perspectives [J].

Blasberg, RG ;

Tjuvajev, AG .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (11) :1620-1629

[3] Positron emission tomography neuroreceptor imaging as a tool in drug discovery, research and development [J].

Burns, HD ;

Hamill, TG ;

Eng, W ;

Francis, B ;

Fioravanti, C ;

Gibson, RE .

CURRENT OPINION IN CHEMICAL BIOLOGY, 1999, 3 (04) :388-394

[4] Advances in vivo bioluminescence imaging of gene expression [J].

Contag, CH ;

Bachmann, MH .

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 2002, 4 :235-260

[5] Quantitative imaging of the T cell antitumor response by positron-emission tomography [J].

Dubey, P ;

Su, H ;

Adonai, N ;

Du, SY ;

Rosato, A ;

Braun, J ;

Gambhir, SS ;

Witte, ON .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (03) :1232-1237

[6] Protease sensors for bioimaging [J].

Funovics, M ;

Weissleder, R ;

Tung, CH .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2003, 377 (06) :956-963

[7]

GAMBHIR SS, COMMUNICATION

[8] PET studies with carbon-11 radioligands in neuropsychopharmacological drug development [J].

Halldin, C ;

Gulyás, B ;

Farde, L .

CURRENT PHARMACEUTICAL DESIGN, 2001, 7 (18) :1907-1929

[9] Non-invasive imaging of reporter genes [J].

Herschman, HR .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2002, :36-44

[10]

HERSCHMAN HR, 2002, VECTOR TARGETING THE, P661