New synthesis of 7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]hept-2-ene.: A key intermediate in the synthesis of epibatidine and analogs

被引：23

作者：

Brieaddy, LE ^{[1
]}

Liang, F ^{[1
]}

Abraham, P ^{[1
]}

Lee, JR ^{[1
]}

Carroll, FI ^{[1
]}

机构：

[1] Res Triangle Inst, Res Triangle Pk, NC 27709 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 30期

关键词：

D O I：

10.1016/S0040-4039(98)01077-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new, high yield, convenient synthesis of 7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]hept-2-ene which involved the addition of tributyltin hydride to 7-(tert-butoxycarbonyl)-2-p-toluenesulfonyl-7-azabicyclo[2.2.1]-2-ene followed by elimination of the tributyltin and p-tolylsulfonyl groups using tetrabutylammonium fluoride was developed. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：5321 / 5322

页数：2

共 10 条

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