MicroRNAs as Regulators of Differentiation and Cell Fate Decisions

被引：391

作者：

Ivey, Kathryn N. ^{[1
,2
,3
,4
]}

Srivastava, Deepak ^{[1
,2
,3
,4
]}

机构：

[1] Univ Calif San Francisco, Gladstone Inst Cardiovasc Dis, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Dept Biochem, San Francisco, CA 94158 USA

[4] Univ Calif San Francisco, Dept Biophys, San Francisco, CA 94158 USA

来源：

CELL STEM CELL | 2010年 / 7卷 / 01期

关键词：

MUSCLE-SPECIFIC MICRORNA; EMBRYONIC STEM-CELLS; SKELETAL-MUSCLE; TARGET; PROLIFERATION; CARDIOGENESIS; PROGRAM; HEART; CYCLE; MICE;

D O I：

10.1016/j.stem.2010.06.012

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Unique expression domains, targets, and gain- and loss-of-function phenotypes of particular microRNAs have important implications for directed differentiation of stem cell populations and suppression of undesired cell types. We discuss this emerging topic, in part using muscle differentiation as a paradigm, and highlight common themes and unique modalities by which microRNAs exert their lineage-promoting or differentiation effects on multiple tissues.

引用

收藏

页码：36 / 41

页数：6

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