The role of N-methyl-D-aspartate (NMDA) receptors in pain:: A review

被引：505

作者：

Petrenko, AB ^{[1
]}

Yamakura, T ^{[1
]}

Baba, A ^{[1
]}

Shimoji, K ^{[1
]}

机构：

[1] Niigata Univ, Sch Med, Dept Anesthesiol, Niigata 9518510, Japan

来源：

ANESTHESIA AND ANALGESIA | 2003年 / 97卷 / 04期

关键词：

D O I：

10.1213/01.ANE.0000081061.12235.55

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

There is accumulating evidence to implicate the importance of N-methyl-D-aspartate (NMDA) receptors to the induction and maintenance of central sensitization during pain states. However, NMDA receptors may also mediate peripheral sensitization and visceral pain. NMDA receptors are,composed of NR1, NR2 (A, B, C, and D), and NR3 (A and B) subunits, which determine the functional properties of native NMDA receptors. Among NMDA receptor subtypes, the NR2B subunit-containing receptors appear particularly important for nociception, thus leading to the possibility that NR2B-selective antagonists may be useful in the treatment of chronic pain.

引用

页码：1108 / 1116

页数：9

共 79 条

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