Epigenetic Reprogramming in Plant and Animal Development

被引：876

作者：

Feng, Suhua ^{[1
,2
]}

Jacobsen, Steven E. ^{[1
,2
]}

Reik, Wolf ^{[3
,4
]}

机构：

[1] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USA

[3] Babraham Inst, Lab Dev Genet & Imprinting, Cambridge CB22 3AT, England

[4] Univ Cambridge, Ctr Trophoblast Res, Cambridge CB2 3EG, England

来源：

SCIENCE | 2010年 / 330卷 / 6004期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

PRIMORDIAL GERM-CELLS; ZYGOTIC PATERNAL GENOME; DNA METHYLATION; STEM-CELLS; MOUSE OOCYTES; HISTONE H3; DEMETHYLATION; ARABIDOPSIS; GENE; CHROMATIN;

D O I：

10.1126/science.1190614

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Epigenetic modifications of the genome are generally stable in somatic cells of multicellular organisms. In germ cells and early embryos, however, epigenetic reprogramming occurs on a genome-wide scale, which includes demethylation of DNA and remodeling of histones and their modifications. The mechanisms of genome-wide erasure of DNA methylation, which involve modifications to 5-methylcytosine and DNA repair, are being unraveled. Epigenetic reprogramming has important roles in imprinting, the natural as well as experimental acquisition of totipotency and pluripotency, control of transposons, and epigenetic inheritance across generations. Small RNAs and the inheritance of histone marks may also contribute to epigenetic inheritance and reprogramming. Reprogramming occurs in flowering plants and in mammals, and the similarities and differences illuminate developmental and reproductive strategies.

引用

页码：622 / 627

页数：6

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