Asymmetric synthesis of 1-Boc-3- and 4-hydroxypyrrolidines

被引：8

作者：

Aoyagi, Y ^{[1
]}

Williams, RM ^{[1
]}

机构：

[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

来源：

TETRAHEDRON | 1998年 / 54卷 / 43期

关键词：

amino acids and derivatives; asymmetric synthesis; pyrrolidines; allylation;

D O I：

10.1016/S0040-4020(98)00807-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lewis Acid-mediated coupling reactions of (5R, 6S)-2-acetoxy-4-(benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazine (2a) with allylsilanes (3a-d) proceeded to give the coupling products (4a-b) with moderate to good stereoselectivity. The coupling products (4a-b) were effectively converted into 1-Boc-3-and 4-hydroxypyrrolidines (8a, syn-b, and c). (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：13045 / 13058

页数：14

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