Is caffeine associated with bone mineral density in young adult women?

被引:43
作者
Conlisk, AJ
Galuska, DA
机构
[1] Emory Univ, Div Biol & Biomed Sci, Nutr & Hlth Sci Program, Atlanta, GA 30322 USA
[2] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA
关键词
BMD; caffeine; calcium; osteoporosis;
D O I
10.1006/pmed.2000.0742
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background. By increasing the urinary excretion of calcium, caffeine consumption may reduce bone mineral density (BMD) and subsequently increase the risk for osteoporotic fracture, Although negative associations between caffeine consumption and BMD have been reported for postmenopausal women, in particular for those who consume low amounts of dietary calcium, the relation between caffeine and BMD in younger women is unclear. Therefore, we evaluated the association between caffeine consumption and BMD in a cross-sectional study of 177 healthy white women, age 19-26 years, who attended a Midwestern university. Methods. Average caffeine intake (milligrams per day) was calculated from self-reports of the consumption of coffee, decaffeinated coffee, tea, colas, chocolate products, and select medications during the previous 12 months (mean caffeine intake = 99.9 mg/day), BMD (grams per square centimeter) at the femoral neck and the lumbar spine was measured by dual-energy X-ray absorptiometry. Results, After adjusting in Linear regression models for potential confounders, including height, body mass index, age at menarche, calcium intake, protein consumption, alcohol consumption, and tobacco use, caffeine consumption was not a significant predictor of BMD. For every 100 mg of caffeine consumed, femoral neck BMD decreased 0.0069 g/cm(2) (95% confidence interval [CI] = -0.0215, 0.0076) and lumbar spine BMD decreased 0.0119 g/cm(2) (95% CI = -0.0271, 0.0033), No single source of caffeine was significantly associated with a decrease in BMD, Furthermore, the association between caffeine consumption and BMD at either site did not differ significantly between those who consumed low levels of calcium (less than or equal to 836 mg/day) and those who consumed high levels of calcium (>836 mg/day), Conclusions, Caffeine intake in the range consumed by young adult women is not an important risk factor for low BMD.
引用
收藏
页码:562 / 568
页数:7
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