Microbial factors leading to recurrent upper respiratory tract infections

被引:12
作者
Brook, I [1 ]
机构
[1] Georgetown Univ, Dept Pediat, Washington, DC 20057 USA
关键词
antimicrobial resistance; penicillin; cephalosporins; beta-lactamase production; bacterial interference;
D O I
10.1097/00006454-199808001-00003
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The treatment or prophylaxis of upper respiratory tract infections such as otitis media, sinusitis and tonsillitis with penicillins can generate bacterial resistance caused by production of beta-lactamase or changes in the penicillin-binding proteins, This resistance can spread in the community even to untreated individuals, The prevalence of resistant organisms tends to increase in the winter months. Beta-lactamase-producing bacteria may interfere with the eradication of penicillin-susceptible organisms and may account for substantial numbers of therapeutic failures among cases of otitis media, sinusitis and tonsillitis, The presence of normal flora that possess interfering capabilities against potential pathogens is beneficial to the host, Such flora may enhance recovery and prevent infections of the tonsils by group A beta-hemolytic streptococci. Therapeutic use of antimicrobial agents that preserve the normal flora but overcome penicillin-susceptible or -resistant pathogens may enhance recovery hom upper respiratory tract infections.
引用
收藏
页码:S62 / S67
页数:6
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