A big step in the study of small cell lung cancer

被引:29
作者
Minna, JD
Kurie, JM
Jacks, T
机构
[1] Univ Texas, SW Med Ctr, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75390 USA
[2] Univ Texas, MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA
[3] MIT, Ctr Canc Res, Cambridge, MA 02142 USA
关键词
D O I
10.1016/S1535-6108(03)00221-6
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A rationally designed, conditional p53 and Rb allele-based and lung-targeted mouse model of human small cell lung cancer (SCLC) provides the cancer research community with a valid and important new tool to use in translational research against this deadly disease.
引用
收藏
页码:163 / 166
页数:4
相关论文
共 22 条
[1]   Initial evaluation of the patient with lung cancer - Symptoms, signs, laboratory tests, and paraneoplastic syndromes [J].
Beckles, MA ;
Spiro, SG ;
Colice, GL ;
Rudd, RM .
CHEST, 2003, 123 (01) :97S-104S
[2]   Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes [J].
Fisher, GH ;
Wellen, SL ;
Klimstra, D ;
Lenczowski, JM ;
Tichelaar, JW ;
Lizak, MJ ;
Whitsett, JA ;
Koretsky, A ;
Varmus, HE .
GENES & DEVELOPMENT, 2001, 15 (24) :3249-3262
[3]  
Ihde Daniel C., 1997, P911
[4]   Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras [J].
Jackson, EL ;
Willis, N ;
Mercer, K ;
Bronson, RT ;
Crowley, D ;
Montoya, R ;
Jacks, T ;
Tuveson, DA .
GENES & DEVELOPMENT, 2001, 15 (24) :3243-3248
[5]   Somatic activation of the K-ras oncogene causes early onset lung cancer in mice [J].
Johnson, L ;
Mercer, K ;
Greenbaum, D ;
Bronson, RT ;
Crowley, D ;
Tuveson, DA ;
Jacks, T .
NATURE, 2001, 410 (6832) :1111-1116
[6]   Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer [J].
Jonkers, J ;
Meuwissen, R ;
van der Gulden, H ;
Peterse, H ;
van der Valk, M ;
Berns, A .
NATURE GENETICS, 2001, 29 (04) :418-425
[7]   Primary lung tumors in mice as an aid for understanding, preventing, and treating human adenocarcinoma of the lung [J].
Malkinson, AM .
LUNG CANCER, 2001, 32 (03) :265-279
[8]   Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene [J].
Meuwissen, R ;
Linn, SC ;
van der Valk, M ;
Mooi, WJ ;
Berns, A .
ONCOGENE, 2001, 20 (45) :6551-6558
[9]   Focus on lung cancer [J].
Minna, JD ;
Roth, JA ;
Gazdar, AF .
CANCER CELL, 2002, 1 (01) :49-52
[10]  
PASS HI, 2000, LUNG CANC PRINCIPLES