Expression of matrix G1a protein (MGP) in an in vitro model of vascular calcification

被引：65

作者：

Mori, K ^{[1
]}

Shioi, A ^{[1
]}

Jono, S ^{[1
]}

Nishizawa, Y ^{[1
]}

Morii, H ^{[1
]}

机构：

[1] Osaka City Univ, Sch Med, Dept Internal Med 2, Abeno Ku, Osaka 5458586, Japan

来源：

FEBS LETTERS | 1998年 / 433卷 / 1-2期

关键词：

matrix Gla protein; beta-glycerophosphate; vascular calcification; atherosclerosis; vascular smooth muscle cell; bisphosphonate;

D O I：

10.1016/S0014-5793(98)00870-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To investigate the role of matrix Gla protein (MGP), which can bind mineral ions through gamma-carboxylated glutamic acid residues, in vascular calcification, me examined the expression of MGP in an in vitro calcification model by using bovine vascular smooth muscle cells (BVSMC), The expression of MGP mRNA mas decreased during BVSMC calcification and its levels were inversely correlated with the quantities of BVSMC calcification. MGP mRNA expression was restored to the level of uncalcified control by inhibiting BVSMC calcification with bisphosphonates, These data suggest that the expression of MGP gene is modulated in the development of vascular calcification, (C) 1998 Federation of European Biochemical Societies.

引用

页码：19 / 22

页数：4

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