Expression of mRNA coding for the serotonin transporter in aged vs young rat brain: Differential effects of glucocorticoids

被引：40

作者：

Fumagalli, F

Jones, SR

Caron, MG

Seidler, FJ

Slotkin, TA

机构：

[1] DUKE UNIV, MED CTR, DEPT PHARMACOL, DURHAM, NC 27710 USA

[2] DUKE UNIV, MED CTR, HOWARD HUGHES MED INST, DURHAM, NC 27710 USA

[3] DUKE UNIV, MED CTR, DEPT CELL BIOL, DURHAM, NC 27710 USA

来源：

BRAIN RESEARCH | 1996年 / 719卷 / 1-2期

关键词：

aging; depression; dexamethasone; glucocorticoid; serotonin transporter;

D O I：

10.1016/0006-8993(96)00119-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Serotonin transporter mRNA expression in midbrain of young and aged rats was measured after long-term infusion of dexamethasone (0.01 and 0.05 mg/kg/day). Aging alone had no effect. Dexamethasone significantly decreased expression in both young and old rats but the effect was greater in the aged group. Adrenocortical dysregulation is common in elderly depression; our results suggest that glucocorticoids interact with aging to exacerbate abnormalities of serotonergic function, contributing to reduced antidepressant effectiveness.

引用

页码：225 / 228

页数：4

共 40 条

[1] Andersen B, 1990, J AFFECT DISORDERS, V18, P289
[2] EFFECT OF ADRENALECTOMY AND CORTICOSTERONE ON [H-3] IMIPRAMINE BINDING IN RAT-BLOOD PLATELETS AND BRAIN
ARORA, RC
MELTZER, HY
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 123 (03) : 415 - 419
[3] CLONING AND EXPRESSION OF A FUNCTIONAL SEROTONIN TRANSPORTER FROM RAT-BRAIN
BLAKELY, RD
BERSON, HE
FREMEAU, RT
CARON, MG
PEEK, MM
PRINCE, HK
BRADLEY, CC
[J]. NATURE, 1991, 354 (6348) : 66 - 70
[4] BRILEY M, 1985, NEUROPHARMACOLOGY SE, P50
[5] CORTICOSTEROIDS IN BRAIN-TISSUE
CARROLL, BJ
HEATH, B
JARRETT, DB
[J]. ENDOCRINOLOGY, 1975, 97 (02) : 290 - 300
[6] CEREBROSPINAL-FLUID AND PLASMA-FREE CORTISOL CONCENTRATIONS IN DEPRESSION
CARROLL, BJ
CURTIS, GC
MENDELS, J
[J]. PSYCHOLOGICAL MEDICINE, 1976, 6 (02) : 235 - 244
[7] CARROLL BJ, 1981, ARCH GEN PSYCHIAT, V38, P15
[8] SEROTONIN UPTAKE AND IMIPRAMINE BINDING IN RAT PLATELETS AFTER CHRONIC DEXAMETHASONE AND AMITRIPTYLINE TREATMENT
CHAN, MY
LEE, PHK
[J]. PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 1985, 17 (07): : 619 - 632
[9] SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION
CHOMCZYNSKI, P
SACCHI, N
[J]. ANALYTICAL BIOCHEMISTRY, 1987, 162 (01) : 156 - 159
[10] DAHLSTROM A, 1964, ACTA PHYSIOL SCAND, V62, P1

← 1 2 3 4 →