Chemotherapy-evoked painful peripheral neuropathy

被引：85

作者：

Polomano, RC ^{[1
]}

Bennett, GJ

机构：

[1] Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Anesthesiol, Hershey, PA 17033 USA

[2] Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Neurosci, Hershey, PA 17033 USA

[3] Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Anat, Hershey, PA 17033 USA

[4] Med Coll Penn & Hahnemann Univ, Dept Neurol, Philadelphia, PA 19102 USA

来源：

PAIN MEDICINE | 2001年 / 2卷 / 01期

关键词：

allodynia; chemotherapy neurotoxicity; hyperalgesia; neuropathy; paclitaxel; painful neuropathy; vincristine;

D O I：

10.1046/j.1526-4637.2001.002001008.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Vincristine and paclitaxel, two of the most effective drugs in the battle against cancer, produce a dose-limiting neurotoxicity that sometimes presents as a painful peripheral neuropathy. For the first time, investigators have been able to produce these chemotherapy-evoked painful peripheral neuropathies in the laboratory rat. These new models have already begun to elucidate the causes of the neuropathic pain associated with these antineoplastic drugs, which will now make it possible to search for effective ways to prevent and treat it.

引用

页码：8 / 14

页数：7

共 49 条

[1] INCREASED RESPONSIVENESS OF SENSORY NEURONS IN THE SAPHENOUS NERVE OF THE STREPTOZOTOCIN-DIABETIC RAT [J].

AHLGREN, SC ;

WHITE, DM ;

LEVINE, JD .

JOURNAL OF NEUROPHYSIOLOGY, 1992, 68 (06) :2077-2085

[2] Vincristine hyperalgesia in the rat: A model of painful vincristine neuropathy in humans [J].

Aley, KO ;

Reichling, DB ;

Levine, JD .

NEUROSCIENCE, 1996, 73 (01) :259-265

[3] NERVE GROWTH-FACTOR PREVENTS TOXIC NEUROPATHY IN MICE [J].

APFEL, SC ;

LIPTON, RB ;

AREZZO, JC ;

KESSLER, JA .

ANNALS OF NEUROLOGY, 1991, 29 (01) :87-90

[4] Pain related behaviour during vincristine-induced neuropathy in rats [J].

Authier, N ;

Coudore, F ;

Eschalier, A ;

Fialip, J .

NEUROREPORT, 1999, 10 (05) :965-968

[5] Amelioration of experimental cisplatin and paclitaxel neuropathy with glutamate [J].

Boyle, FM ;

Wheeler, HR ;

Shenfield, GM .

JOURNAL OF NEURO-ONCOLOGY, 1999, 41 (02) :107-116

[6]

Campana WM, 1998, NEUROTOXICOLOGY, V19, P237

[7]

Cavaletti G, 1997, NEUROTOXICOLOGY, V18, P137

[8] EXPERIMENTAL PERIPHERAL NEUROPATHY INDUCED IN ADULT-RATS BY REPEATED INTRAPERITONEAL ADMINISTRATION OF TAXOL [J].

CAVALETTI, G ;

TREDICI, G ;

BRAGA, M ;

TAZZARI, S .

EXPERIMENTAL NEUROLOGY, 1995, 133 (01) :64-72

[9]

Chabner BA, 1985, PRINCIPLES PRACTICE, V1, P287

[10] PERIPHERAL NEUROPATHY FROM TAXOL AND CISPLATIN COMBINATION CHEMOTHERAPY - CLINICAL AND ELECTROPHYSIOLOGICAL STUDIES [J].

CHAUDHRY, V ;

ROWINSKY, EK ;

SARTORIUS, SE ;

DONEHOWER, RC ;

CORNBLATH, DR .

ANNALS OF NEUROLOGY, 1994, 35 (03) :304-311

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