Sphingosine kinase: a mediator of vital cellular functions

被引：140

作者：

Olivera, A ^{[1
]}

Spiegel, S ^{[1
]}

机构：

[1] Georgetown Univ, Med Ctr, Dept Biochem & Mol Biol, Washington, DC 20007 USA

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2001年 / 64卷 / 1-4期

关键词：

sphingosine kinase; sphingosine-1-phosphate; cell growth; cell death;

D O I：

10.1016/S0090-6980(01)00108-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ample evidence indicates that sphingosine-1-phosphate (SPP) can serve as an intracellular second messenger regulating calcium mobilization, and cell growth and survival. Moreover, the dynamic balance between levels of the sphingolipids metabolites, ceramide and SPP, and consequent regulation of opposing signaling pathways, is an important factor that determines whether a cell survives or dies. SPP has also recently been shown to be the ligand fur the EDG-1 family of G protein-coupled receptors, which now includes EDG-1, -3, -5, -6, and -8. SPP is thus a lipid mediator that has novel dual actions signaling inside and outside of the cell. This review is focussed on sphingosine kinase, the enzyme that regulates levels of SPP and thus plays a critical role in diverse biological processes. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：123 / 134

页数：12

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