No genetic bottleneck in Plasmodium falciparum wild-type pfcrt alleles reemerging in Hainan Island, China, following high-level chloroquine resistance

被引：15

作者：

Chen, Nanhua ^{[1
]}

Gao, Qi ^{[2
]}

Wang, Shanqing ^{[3
]}

Wang, Guangze ^{[3
]}

Gatton, Michelle ^{[4
]}

Cheng, Qin ^{[1
,4
]}

机构：

[1] Australian Army Malaria Inst, Dept Drug Resistance & Diagnost, Enoggera, Qld 4051, Australia

[2] Jiangsu Inst Parasit Dis, Jiangsu, Peoples R China

[3] Hainan Prov Ctr Dis Control & Prevent, Haikou, Hainan, Peoples R China

[4] Queensland Inst Med Res, Malaria Drug Resistance & Diagnost, Brisbane, Qld 4006, Australia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 01期

关键词：

D O I：

10.1128/AAC.00711-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Chloroquine-resistant Plasmodium falciparum was highly prevalent in Hainan, China, in the 1970s. Twenty-five years after cessation of chloroquine therapy, the prevalence of P. falciparum wild-type Pfcrt alleles has risen to 36% (95% confidence interval, 22.1 to 52.4%). The diverse origins of wild-type alleles indicate that there was no genetic bottleneck caused by high chloroquine resistance.

引用

页码：345 / 347

页数：3

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