Regulation of the neutrophil-mediated inflammatory response to infection

被引:93
作者
Kobayashi, SD [1 ]
Voyich, JM [1 ]
DeLeo, FR [1 ]
机构
[1] NIAID, Rocky Mt Labs, Lab Human Bacterial Pathogenesis, NIH, Hamilton, MT 59840 USA
关键词
inflammation; neutrophils; phagocytosis; apoptosis; HUMAN POLYMORPHONUCLEAR LEUKOCYTES; GROUP-A STREPTOCOCCUS; APOPTOSIS; PROTEIN; LIPOPOLYSACCHARIDE; RECOGNITION; DESTRUCTION; SALMONELLA; ACTIVATION; EXPRESSION;
D O I
10.1016/j.micinf.2003.09.013
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Human polymorphonuclear leukocytes (PMNs) are the first line of defense against invading microorganisms and contribute significantly to inflammation. Recent evidence suggests that resolution of neutrophil-mediated inflammation is facilitated by an apoptosis differentiation program, a final stage of transcriptionally regulated PMN maturation that is accelerated significantly by phagocytosis. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码:1337 / 1344
页数:8
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