Modification of tissue factor by peroxynitrite influences its procoagulant activity

被引：11

作者：

Adam, JM ^{[1
]}

Ettelaie, C ^{[1
]}

Naseem, KM ^{[1
]}

James, NJ ^{[1
]}

Bradley, NJ ^{[1
]}

Bruckdorfer, KR ^{[1
]}

机构：

[1] Royal Free Hosp, Sch Med, Dept Biochem & Mol Biol, London NW3 2PF, England

来源：

FEBS LETTERS | 1998年 / 429卷 / 03期

关键词：

atherosclerosis; peroxynitrite; tissue factor; procoagulant activity; nitration;

D O I：

10.1016/S0014-5793(98)00627-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peroxynitrite, a reactive oxidising species resulting from a reaction between nitric oxide and the superoxide anion, modifies proteins by nitration of certain amino acids such as tyrosine. Tissue factor (TF), a transmembrane protein, is expressed on cells under inflammatory conditions and initiates the coagulation cascade. The extracellular domain of TF is rich in tyrosine, Exposure of recombinant TF and cellular TF to peroxynitrite was associated with a reduction in procoagulant activity. This was accompanied by an elevated level of nitrotyrosine residues, Peroxynitrite may hale a protective role by attenuation of the thrombotic properties of TF. (C) 1998 Federation of European Biochemical Societies.

引用

页码：347 / 350

页数：4

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