Dendritic Cells in Alcoholic Liver Injury and Fibrosis

被引：8

作者：

Aloman, Costica ^{[1
]}

Friedman, Scott L. ^{[1
]}

Merad, Miriam ^{[2
]}

机构：

[1] Mt Sinai Sch Med, Div Liver Dis, Dept Med, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Dept Gene & Cell Med, New York, NY 10029 USA

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 2011年 / 35卷 / 05期

关键词：

Dendritic Cells; Liver Fibrosis; Immune Responses; Acute Alcoholic Liver Injury; NATURAL-KILLER-CELLS; CHRONIC ETHANOL-CONSUMPTION; CELLULAR IMMUNE-RESPONSES; COLONY-STIMULATING FACTOR; ACTIVATED STELLATE CELLS; RECEPTOR-ALPHA-CHAIN; HEPATITIS-C; IN-VIVO; FLT3; LIGAND; HISTOLOGICAL ANALYSIS;

D O I：

10.1111/j.1530-0277.2010.01397.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

100404 [儿少卫生与妇幼保健学];

摘要：

Alcohol consumption impairs the development of innate and adaptive immune responses, however the exact mechanism by which alcohol leads to immune defects remains to be established. Dendritic cells (DCs) form a heterogeneous population of hematopoietic cells that are present in all tissues including the liver. DC are initially described playing a key role in the induction of innate and adaptive immune response against specific antigens. In our presentation, we discussed few new aspects of DC development, critical assessment of DC in non-lymphoid organs and the impact of alcohol consumption on DC function. Understanding the mechanism by which DC modulate liver function after alcohol consumption may help uncover novel therapeutic strategies for the treatment of these conditions.

引用

页码：776 / 781

页数：6

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