Epidemiology of hypersensitivity drug reactions

被引:347
作者
Gomes, ER [1 ]
Demoly, P [1 ]
机构
[1] Univ Hosp Montpellier, Hop Arnaud Villeneuve, Head Allergy Dept, F-34295 Montpellier, France
关键词
adverse drug reactions; drug hypersensitivity; incidence; prevalence; risk factors;
D O I
10.1097/01.all.0000173785.81024.33
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Purpose of review Hypersensitivity drug reactions are but one of the many different types of adverse drug reactions. They may be potentially life-threatening, prolong hospitalization, affect drug prescribing patterns of physicians and result in socioeconomic costs. This review summarizes current knowledge on the incidence, prevalence, mortality and risk factors for these reactions in different populations. Recent findings Hypersensitivity reactions represent about one third of all adverse drug reactions. Adverse drug reactions affect 10-20% of hospitalized patients and more than 7% of the general population. Severe reactions including anaphylaxis, drug hypersensitivity syndromes, Stevens Johnson syndrome and toxic epidermal necrolysis are also associated with significant morbidity and mortality. Although several risk factors have been identified, their clinical importance has not been fully understood. Future progress in immunogenetics and pharacogenetics may help identify populations at risk for specific types of reactions. Summary Well designed epidemiological studies on hypersensitivity drug reaction are lacking as most studies have been on adverse drug reactions. Such studies will be helpful in identifying patients at risk of developing such reactions, in particular severe reactions, and implementing early preventive measures.
引用
收藏
页码:309 / 316
页数:8
相关论文
共 85 条
[1]  
[Anonymous], 1991, Lancet, V337, P1308
[2]   Represcription of penicillin after allergic-like events [J].
Apter, AJ ;
Kinman, JL ;
Bilker, WB ;
Herlim, M ;
Margolis, DJ ;
Lautenbach, E ;
Hennessy, S ;
Strom, BL .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2004, 113 (04) :764-770
[3]   Joining the DoTS: new approach to classifying adverse drug reactions [J].
Aronson, JK ;
Ferner, RE .
BRITISH MEDICAL JOURNAL, 2003, 327 (7425) :1222-1225
[4]  
ARONSON JK, 2002, DAVIDSONS PRINCIPLES, P147
[5]   Detection of patients with multiple drug allergy syndrome by elective tolerance tests [J].
Asero, R .
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 1998, 80 (02) :185-188
[6]   Under-reporting of serious adverse drug reactions in Sweden [J].
Bäckström, M ;
Mjörndal, T ;
Dahlqvist, R .
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2004, 13 (07) :483-487
[7]  
Barranco P., 1998, CLIN EXP ALLERGY, V28, pS61
[8]   INCIDENCE OF ADVERSE DRUG EVENTS AND POTENTIAL ADVERSE DRUG EVENTS - IMPLICATIONS FOR PREVENTION [J].
BATES, DW ;
CULLEN, DJ ;
LAIRD, N ;
PETERSEN, LA ;
SMALL, SD ;
SERVI, D ;
LAFFEL, G ;
SWEITZER, BJ ;
SHEA, BF ;
HALLISEY, R ;
VANDERVLIET, M ;
NEMESKAL, R ;
LEAPE, LL .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 274 (01) :29-34
[9]   Anticonvulsant hypersensitivity syndrome: Lymphocyte toxicity assay for the confirmation of diagnosis and risk assessment [J].
Bavdekar, SB ;
Muranjan, MN ;
Gogtay, NJ ;
Kantharia, V ;
Kshirsagar, NA .
ANNALS OF PHARMACOTHERAPY, 2004, 38 (10) :1648-1650
[10]  
BIGBY JM, 1986, JAMA-J AM MED ASSOC, V258, P3358