Protein-sparing therapy after major abdominal surgery - Lack of clinical effects

被引：33

作者：

Doglietto, GB

Gallitelli, L

Pacelli, F

Bellantone, R

Malerba, M

Sgadari, A

Crucitti, F

Gaggiotti, G

Carrata, R

Lippolis, A

Morgese, A

Martino, D

Lattarulo, V

Margiotta, F

DaRold, A

Roversi, CA

Fontana, A

Nicodemo, P

Leone, V

Tonelli, P

Bonera, A

Alberti, P

Zanni, F

Scuderi, C

Terranova, ML

Braga, M

Gianotti, L

Galli, E

Corti, T

Maggioni, D

Marzari, A

Aseni, P

Mercurio, A

DeSiena, M

Giombolini, A

Annesi, L

Lolli, A

Pasquale, R

DeSantis, L

Casoni, P

Botta, P

Paolo, D

Vassili, J

Morelli, G

Doglietto, JB

Carriero, C

Valentini, L

Sasso, F

DiPinto, A

Gulino, G

机构：

[1] UNIV CATTOLICA SACRO CUORE,IST CLIN CHIRURG,I-00168 ROME,ITALY

[2] UNIV CATTOLICA SACRO CUORE,IST CLIN MED,I-00168 ROME,ITALY

[3] OSPED NIGUARDA CA GRANDA,DIV PIZZAMIGLIO 1,MILAN,ITALY

[4] INRCA ANCONA,ANCONA,ITALY

[5] OSPED MAZZOLI,ASCOLI,ITALY

[6] UNIV BARI,BARI,ITALY

[7] OSPED VENERE,BARI,ITALY

[8] CASE CURA RIUNITE,BARI,ITALY

[9] OSPED BELLUNO,BELLUNO,ITALY

[10] POLICLIN S ORSOLA,BOLOGNA,ITALY

[11] USL 26,BUSSOLENGO,ITALY

[12] POLICLIN CAREGGI,FLORENCE,ITALY

[13] OSPED O BASILEWSKY,FLORENCE,ITALY

[14] OSPED GAVARDO,GAVARDO,ITALY

[15] USL 1,LUINO,ITALY

[16] UNIV MESSINA POLICLIN,MESSINA,ITALY

[17] OSPED SAN RAFFAELE,MILAN,ITALY

[18] OSPED NUOVO PELLEGRINI,NAPLES,ITALY

[19] USL,NARNI,ITALY

[20] USL 21,PADUA,ITALY

[21] OSPED MAGGIORE PARMA,PARMA,ITALY

[22] POLICLIN SAN MATTEO,I-27100 PAVIA,ITALY

[23] USL 14,RECANATI,ITALY

[24] UNIV CATTOLICA SACRO CUORE,IST PATOL CHIRURG,ROME,ITALY

[25] USL 22,S BENEDETTO DEL TRONTO,ITALY

[26] UNIV SIENA,I-53100 SIENA,ITALY

[27] OSPED CIV S ANNUNZIATA,TARANTO,ITALY

[28] OSPED TREVIGLIO,TREVIGLIO,ITALY

[29] OSPED CATTINARA,TRIESTE,ITALY

[30] OSPED CIVILE,I-37126 VERONA,ITALY

[31] OSPED BEL COLLE,VITERBO,ITALY

来源：

ANNALS OF SURGERY | 1996年 / 223卷 / 04期

关键词：

D O I：

10.1097/00000658-199604000-00003

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Objective A prospective multicenter randomized trial was designed to evaluate the clinical efficacy of postoperative protein-sparing therapy. Summary Background Data The metabolic effect of postoperative protein-sparing therapy has been shown by several studies, but the clinical utility of this treatment has not been investigated by large prospective trials. Methods Six hundred seventy-eight patients undergoing major elective abdominal surgery were randomly assigned to receive either protein-sparing therapy after surgery (protein-sparing therapy group) or conventional therapy (control group). The patients were monitored for postoperative complications and mortality. Results The rate of major postoperative complications was similar in both groups (protein-sparing therapy group, 19.5%; control group, 20.9%; p = 0.66) as were the overall postoperative mortality rates (4.7% and 3.5%, respectively; p = 0.43). Conclusions The present study indicates that routine protein-sparing therapy for patients normonourished or mildly malnourished undergoing major abdominal surgery is not clinically justified.

引用

页码：357 / 362

页数：6

共 7 条

[1] PREOPERATIVE PARENTERAL-NUTRITION IN THE HIGH-RISK SURGICAL PATIENT [J].