Natural compounds: Leads or ideas? Bioinspired molecules for drug discovery

被引：72

作者：

Beghyn, Terence ^{[1
,2
,3
]}

Deprez-Poulain, Rebecca ^{[1
,2
,3
]}

Willand, Nicolas ^{[1
,2
,3
]}

Folleas, Benoit ^{[4
]}

Deprez, Benoit ^{[1
,2
,3
,4
]}

机构：

[1] INSERM, U761, F-59006 Lille, France

[2] Univ Lille 2, Fac Pharm, F-59006 Lille, France

[3] Inst Pasteur, IFR 142, F-59021 Lille, France

[4] DIVERCHIM SA, F-60765 Montataire, France

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2008年 / 72卷 / 01期

关键词：

bicyclic-lactams; bielectrophile-binucleophile reactions; bioinspiration; biomimicry; complexity of synthesis efficiency index; spirochromanones;

D O I：

10.1111/j.1747-0285.2008.00673.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this article, we compare drugs of natural origin to synthetic compounds and analyze the reasons why natural compounds occupy a place of choice in the current pharmacopoeia. The observations reported here support the design of synthetic compounds inspired from plant alkaloids and their biosynthetic pathway. Our reasoning leads to very efficient syntheses of compounds which complexity matches that of indolomonoterpenic alkaloids.

引用

页码：3 / 15

页数：13

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