Conformationally restricted 1,5-diarylpyrazoles are selective COX-2 inhibitors

被引：50

作者：

Bertenshaw, SR

Talley, JJ

Rogier, DJ

Graneto, MJ

Koboldt, CM

Zhang, Y

机构：

[1] G.D. Searle, St. Louis, MO 63198

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(96)00530-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Benzothiopyranopyrazoles and benzopyranopyrazoles containing either a sulfone or sulfonamide moiety were synthesized and tested for COX-1 and COX-2 inhibition. This new class of COX-2 selective inhibitors possess antiinflammatory activity in vivo. Copyright (C) 1996 Elsevier Science Ltd

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页码：2827 / 2830

页数：4

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