Streptococcus sp and Staphylococcus aureus isolates from patients with psoriasis possess genes that code for toxins (superantigens):: Clinical and therapeutic implications

被引：10

作者：

El Ferezli, Jessica ^{[1
]}

Jenbazian, Lori ^{[1
]}

Rubeiz, Nelly ^{[2
]}

Kibbi, Abdul-Ghani ^{[2
]}

Zaynoun, Shukrallah ^{[2
]}

Abdelnoor, Alexander M. ^{[1
]}

机构：

[1] Amer Univ Beirut, Dept Microbiol & Immunol, Fac Med, Beirut 11072020, Lebanon

[2] Amer Univ Beirut, Dept Dermatol, Fac Med, Beirut 11072020, Lebanon

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 2008年 / 30卷 / 02期

关键词：

psoriasis; Staphylococcus aureus; Streptococcus sp; superantigens; toxins;

D O I：

10.1080/08923970801946808

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Superantigens are powerful T lymphocyte-stimulating agents that are believed to contribute to the pathogenesis of certain diseases such as psoriasis. Toxins produced by Streptococcus pyogenes and Staphylococcus aureus are superantigens. The aim of this study was to detect genes that code for superantigens in Streptococcus and Staphylococcus aureus isolates from psoriatic patients. Primers to amplify streptococcal pyrogenic exotoxin A, B, and C and streptolysin O genes and staphylococcal enterotoxin A, B, C, and D genes were used. Streptococcal exotoxin B was detected in five streptococcal isolates. Staphyloccocus aureus enterotoxin A and/or C genes were detected in nine S. aureus isolates. Isolates from 13 of 22 patients possesed gene(s) that code for toxin(s) (superantigens). These results might support the role of superantigens in the exacerbation of psoriasis.

引用

页码：195 / 205

页数：11

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