Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine

被引：133

作者：

Kaddurah-Daouk, R. ^{[1
,2
]}

Weinshilboum, R. ^{[3
,4
]}

机构：

[1] Duke Univ, Dept Psychiat & Behav Sci, Durham, NC 27708 USA

[2] Duke Univ, Duke Inst Brain Sci, Durham, NC USA

[3] Mayo Clin, Div Clin Pharmacol, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN USA

[4] Mayo Clin, Ctr Individualized Med, Rochester, MN USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2015年 / 98卷 / 01期

关键词：

INFORMED PHARMACOGENOMICS; SERTRALINE; THERAPY; PLACEBO;

D O I：

10.1002/cpt.134

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The scaling up of data in clinical pharmacology and the merger of systems biology and pharmacology has led to the emergence of a new discipline of Quantitative and Systems Pharmacology (QSP). This new research direction might significantly advance the discovery, development, and clinical use of therapeutic drugs. Research communities from computational biology, systems biology, and biological engineering-working collaboratively with pharmacologists, geneticists, biochemists, and analytical chemists-are creating and modeling large data on drug effects that is transforming our understanding of how these drugs work at a network level. In this review, we highlight developments in a new and rapidly growing field-pharmacometabolomics-in which large biochemical data-capturing effects of genome, gut microbiome, and environment exposures is revealing information about metabotypes and treatment outcomes, and creating metabolic signatures as new potential biomarkers. Pharmacometabolomics informs and complements pharmacogenomics and together they provide building blocks for QSP.

引用

页码：71 / 75

页数：5

共 24 条

[1]

Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics [J].

Abo, Ryan ;

Hebbring, Scott ;

Ji, Yuan ;

Zhu, Hongjie ;

Zeng, Zhao-Bang ;

Batzler, Anthony ;

Jenkins, Gregory D. ;

Biernacka, Joanna ;

Snyder, Karen ;

Drews, Maureen ;

Fiehn, Oliver ;

Fridley, Brooke ;

Schaid, Daniel ;

Kamatani, Naoyuki ;

Nakamura, Yusuke ;

Kubo, Michiaki ;

Mushiroda, Taisei ;

Kaddurah-Daouk, Rima ;

Mrazek, David A. ;

Weinshilboum, Richard M. .

PHARMACOGENETICS AND GENOMICS, 2012, 22 (04) :247-253

[2]

Pharmaco-metabonomic phenotyping and personalized drug treatment [J].

Clayton, TA ;

Lindon, JC ;

Cloarec, O ;

Antti, H ;

Charuel, C ;

Hanton, G ;

Provost, JP ;

Le Net, JL ;

Baker, D ;

Walley, RJ ;

Everett, JR ;

Nicholson, JK .

NATURE, 2006, 440 (7087) :1073-1077

[3]

Is Diabetes Mellitus-Linked Amino Acid Signature Associated With β-Blocker-Induced Impaired Fasting Glucose? [J].

Cooper-DeHoff, Rhonda M. ;

Hou, Wei ;

Weng, Liming ;

Baillie, Rebecca A. ;

Beitelshees, Amber L. ;

Gong, Yan ;

Shahin, Mohamed H. A. ;

Turner, Stephen T. ;

Chapman, Arlene ;

Gums, John G. ;

Boyle, Stephen H. ;

Zhu, Hongjie ;

Wikoff, William R. ;

Boerwinkle, Eric ;

Fiehn, Oliver ;

Frye, Reginald F. ;

Kaddurah-Daouk, Rima ;

Johnson, Julie A. .

CIRCULATION-CARDIOVASCULAR GENETICS, 2014, 7 (02) :199-205

[4]

Pharmacometabolomics Reveals That Serotonin Is Implicated in Aspirin Response Variability [J].

Ellero-Simatos, S. ;

Lewis, J. P. ;

Georgiades, A. ;

Yerges-Armstrong, L. M. ;

Beitelshees, A. L. ;

Horenstein, R. B. ;

Dane, A. ;

Harms, A. C. ;

Ramaker, R. ;

Vreeken, R. J. ;

Perry, C. G. ;

Zhu, H. ;

Sanchez, C. L. ;

Kuhn, C. ;

Ortel, T. L. ;

Shuldiner, A. R. ;

Hankemeier, T. ;

Kaddurah-Daouk, R. .

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2014, 3 (07)

[5]

Stable isotope-resolved metabolomic analysis of lithium effects on glial-neuronal metabolism and interactions [J].

Fan, Teresa W-M ;

Yuan, Peixiong ;

Lane, Andrew N. ;

Higashi, Richard M. ;

Wang, Yun ;

Hamidi, Anahita B. ;

Zhou, Rulun ;

Guitart, Xavier ;

Chen, Guang ;

Manji, Husseini K. ;

Kaddurah-Daouk, Rima .

METABOLOMICS, 2010, 6 (02) :165-179

[6]

Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics [J].

Haiser, Henry J. ;

Seim, Kristen L. ;

Balskus, Emily P. ;

Turnbaugh, Peter J. .

GUT MICROBES, 2014, 5 (02) :233-238

[7]

Glycine and a Glycine Dehydrogenase (GLDC) SNP as Citalopram/Escitalopram Response Biomarkers in Depression: Pharmacometabolomics-Informed Pharmacogenomics [J].

Ji, Y. ;

Hebbring, S. ;

Zhu, H. ;

Jenkins, G. D. ;

Biernacka, J. ;

Snyder, K. ;

Drews, M. ;

Fiehn, O. ;

Zeng, Z. ;

Schaid, D. ;

Mrazek, D. A. ;

Kaddurah-Daouk, R. ;

Weinshilboum, R. M. .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2011, 89 (01) :97-104

[8]

Metabolomic mapping of atypical antipsychotic effects in schizophrenia [J].

Kaddurah-Daouk, R. ;

McEvoy, J. ;

Baillie, R. A. ;

Lee, D. ;

Yao, J. K. ;

Doraiswamy, P. M. ;

Krishnan, K. R. R. .

MOLECULAR PSYCHIATRY, 2007, 12 (10) :934-945

[9]

Pharmacometabolomics: Implications for Clinical Pharmacology and Systems Pharmacology [J].

Kaddurah-Daouk, R. ;

Weinshilboum, R. M. .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2014, 95 (02) :154-167

[10]

Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo [J].

Kaddurah-Daouk, R. ;

Bogdanov, M. B. ;

Wikoff, W. R. ;

Zhu, H. ;

Boyle, S. H. ;

Churchill, E. ;

Wang, Z. ;

Rush, A. J. ;

Krishnan, R. R. ;

Pickering, E. ;

Delnomdedieu, M. ;

Fiehn, O. .

TRANSLATIONAL PSYCHIATRY, 2013, 3 :e223-e223

← 1 2 3 →