Fibroblast growth factor receptors (FGFRs) and their roles in limb development

被引：117

作者：

Xu, XL ^{[1
]}

Weinstein, M ^{[1
]}

Li, CL ^{[1
]}

Deng, CX ^{[1
]}

机构：

[1] NIDDKD, Genet Dev & Dis Branch, NIH, Bethesda, MD 20892 USA

来源：

CELL AND TISSUE RESEARCH | 1999年 / 296卷 / 01期

关键词：

FGF-FGF receptors; limb initiation; progress zone activity; hand and foot anomalies;

D O I：

10.1007/s004410051264

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fibroblast growth factor (FGF) receptors constitute a family of four membrane-spanning tyrosine kinases (FGFR1-4) which serve as high-affinity receptors for 17 growth factors (FGF1-17). To study functions of FGF/FGFR signals in development, mice that carry mutations in each receptor have been created by gene targeting. Analysis of these mutant mice revealed essential functions of FGF receptors in multiple biological processes, including mesoderm induction and patterning, cell growth and migration, organ formation and bone growth. In this review we discuss recent work with FGF receptors to illustrate mechanisms. through which the FGF/FGFR signals specify vertebrate limb initiation, outgrowth and patterning.

引用

页码：33 / 43

页数：11

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