GABA and glutamate systems as therapeutic targets in depression and mood disorders

被引：128

作者：

Kendell, SF ^{[1
]}

Krystal, JH ^{[1
]}

Sanacora, G ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06510 USA

来源：

EXPERT OPINION ON THERAPEUTIC TARGETS | 2005年 / 9卷 / 01期

关键词：

depression; GABA; glutamate; mood disorder; NMDA;

D O I：

10.1517/14728222.9.1.153

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Advances made in diverse areas of neuroscience suggest that neurotransmitter systems, additional to the monoaminergic, contribute to the pathophysiology of mood disorders. This ever accruing body of preclinical and clinical research is providing increased recognition of the contribution made by amino acid neurotransmitters to the neurobiology of mood disorders. This review examines evidence supporting the role of GABA and glutamate in these processes and explores the potential to target these systems in the development of novel compounds; the viability of these agents for treatment-related co-morbidities will also be considered.

引用

页码：153 / 168

页数：16

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