Destruction of α-synuclein based amyloid fibrils by a low temperature plasma jet

被引：30

作者：

Karakas, Erdinc ^{[2
]}

Munyanyi, Agatha ^{[1
]}

Greene, Lesley ^{[1
]}

Laroussi, Mounir ^{[2
]}

机构：

[1] Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA

[2] Old Dominion Univ, Laser & Plasma Engn Inst, Norfolk, VA 23529 USA

来源：

APPLIED PHYSICS LETTERS | 2010年 / 97卷 / 14期

关键词：

Atmospheric pressure - Atmospheric temperature - Glycoproteins - Plasma jets;

D O I：

10.1063/1.3499277

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Amyloid fibrils are ordered beta-sheet aggregates that are associated with a number of neurodegenerative diseases such as Alzheimer and Parkinson. At present, there is no cure for these progressive and debilitating diseases. Here we report initial studies that indicate that low temperature atmospheric pressure plasma can break amyloid fibrils into smaller units in vitro. The plasma was generated by the "plasma pencil," a device capable of emitting a long, low temperature plasma plume/jet. This avenue of research may facilitate the development of a plasma-based medical treatment. (C) 2010 American Institute of Physics. [doi:10.1063/1.3499277]

引用

页数：3

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