Adenosine A3 receptors are located in neurons of the rat hippocampus

被引：66

作者：

Lopes, LV

Rebola, N

Pinheiro, PC

Richardson, PJ

Oliveira, CR

Cunha, RA ^{[1
]}

机构：

[1] Univ Coimbra, Fac Med, Inst Biochem, Ctr Neurosci Coimbra, P-3004504 Coimbra, Portugal

[2] Univ Lisbon, Fac Med, Neurosci Lab, P-1699 Lisbon, Portugal

[3] Univ Cambridge, Pharmacol Lab, Cambridge CB2 1TN, England

来源：

NEUROREPORT | 2003年 / 14卷 / 12期

关键词：

adenosine; hippocampus; nerve terminals; neuromodulation; presynaptic;

D O I：

10.1097/00001756-200308260-00021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adenosine is a neuromodulator acting mainly via inhibitory A, and facilitatory A(2A) receptors. Whole tissue PCR also identified adenosine A(3) receptors in the brain and A(3) receptor agonists affect CNS neuronal responses and viability. However, recent reports failed to detect A(3) receptor expression in CNS neurons and showed that A(3) receptor agonists can bind and activate A(1) receptors. We now present evidence for the presence of A(3) receptor mRNA in CNS neurons using single cell PCR analysis of laser dissected hippocampal neurons. Western blot analysis showed that A(3) receptors are present in rat hippocampal nerve terminal membranes. This indicates that A(3) receptors are present in CNS neurons in the hippocampus.

引用

页码：1645 / 1648

页数：4

共 24 条

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