Serotonin (5-HT)2C receptors tonically inhibit dopamine (DA) and noradrenaline (NA), but not 5-HT, release in the frontal cortex in vivo

被引:245
作者
Millan, MJ [1 ]
Dekeyne, A [1 ]
Gobert, A [1 ]
机构
[1] Inst Rech Servier, Dept Psychopharmacol, F-78290 Paris, France
关键词
5-HT2C; receptors; monoamines; dialysis; frontal cortex;
D O I
10.1016/S0028-3908(98)00078-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The novel, preferential 5-HT2C receptor agonist; Ro 60-0175 ((S)-2-(6-chloro-5-fluoroindol-1-yl)-1-metllylethylamine) (2.5 mg/kg, s.c.), markedly suppressed dialysate levels of dopamine (DA) and noradrenaline (NA) levels in the frontal cortex of freely-moving rats without affecting levels of 5-HT. In contrast, the novel and selective 5-HT2C receptor antagonist, SB-242084 (6-chloro-5-methyl-1-[6-(2-methylpyridin-3-yloxy) pyridin-3-yl carbamoyl] indoline) (10.0 mg/kg, i.p.), markedly increased dialysate levels of DA and NA without modifying those of 5-HT. These data suggest that 5-HT2C receptors exert a tonic, inhibitory influence upon frontocortical dopaminergic and adrenergic, but not serotonergic, transmission. (C) 1998 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:953 / 955
页数:3
相关论文
共 10 条
  • [1] Novel agonists of 5HT(2C) receptors. Synthesis and biological evaluation of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2-b]pyrrol-1-yl)-1-methylethylamines. Improved therapeutics for obsessive compulsive disorder
    Bos, M
    Jenck, F
    Martin, JR
    Moreau, JL
    Sleight, AJ
    Wichmann, J
    Widmer, U
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (17) : 2762 - 2769
  • [2] SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist
    Kennett, GA
    Wood, MD
    Bright, F
    Trail, B
    Riley, G
    Holland, V
    Avenell, KY
    Stean, T
    Upton, N
    Bromidge, S
    Forbes, IT
    Brown, AM
    Middlemiss, DN
    Blackburn, TP
    [J]. NEUROPHARMACOLOGY, 1997, 36 (4-5) : 609 - 620
  • [3] Dopamine, the prefrontal cortex and schizophrenia
    Knable, MB
    Weinberger, DR
    [J]. JOURNAL OF PSYCHOPHARMACOLOGY, 1997, 11 (02) : 123 - 131
  • [4] MD K., 1996, Modul. Dopaminergic Neurotransmission by Other Neurotransmitters, P87
  • [5] 5-HT2C receptors mediate penile erections in rats: Actions of novel and selective agonists and antagonists
    Millan, MJ
    Peglion, JL
    Lavielle, G
    PerrinMonneyron, S
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1997, 325 (01) : 9 - 12
  • [6] Millan MJ, 1997, J PHARMACOL EXP THER, V282, P132
  • [7] SYSTEMIC ADMINISTRATION OF AMPEROZIDE, A NEW ATYPICAL ANTIPSYCHOTIC DRUG, PREFERENTIALLY INCREASES DOPAMINE RELEASE IN THE RAT MEDIAL PREFRONTAL CORTEX
    NOMIKOS, GG
    IURLO, M
    ANDERSSON, JL
    KIMURA, K
    SVENSSON, TH
    [J]. PSYCHOPHARMACOLOGY, 1994, 115 (1-2) : 147 - 156
  • [8] ACTIONS OF 5-HYDROXYTRYPTAMINE ON VENTRAL TEGMENTAL AREA NEURONS OF THE RAT IN-VITRO
    PESSIA, M
    JIANG, ZG
    NORTH, RA
    JOHNSON, SW
    [J]. BRAIN RESEARCH, 1994, 654 (02) : 324 - 330
  • [9] DISTRIBUTION OF THE SEROTONIN 5-HT2 RECEPTOR FAMILY MESSENGER-RNAS - COMPARISON BETWEEN 5-HT(2A) AND 5-HT(2C) RECEPTORS
    POMPEIANO, M
    PALACIOS, JM
    MENGOD, G
    [J]. MOLECULAR BRAIN RESEARCH, 1994, 23 (1-2): : 163 - 178
  • [10] INCREASE OF EXTRACELLULAR DOPAMINE IN THE PREFRONTAL CORTEX - A TRAIT OF DRUGS WITH ANTIDEPRESSANT POTENTIAL
    TANDA, G
    CARBONI, E
    FRAU, R
    DICHIARA, G
    [J]. PSYCHOPHARMACOLOGY, 1994, 115 (1-2) : 285 - 288