Immune escape from HIV-specific antibody-dependent cellular cytotoxicity (ADCC) pressure

被引：121

作者：

Chung, Amy W. ^{[1
]}

Isitman, Gamze ^{[1
]}

Navis, Marjon ^{[1
]}

Kramski, Marit ^{[1
]}

Center, Rob J. ^{[1
]}

Kent, Stephen J. ^{[1
,2
,3
]}

Stratov, Ivan ^{[1
,2
,3
]}

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia

[2] Melbourne Sexual Hlth Clin, Carlton, Vic 3053, Australia

[3] Alfred Hosp, Infect Dis Unit, Prahran, Vic 3181, Australia

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2011年 / 108卷 / 18期

基金：

澳大利亚研究理事会; 美国国家卫生研究院; 英国医学研究理事会;

关键词：

natural killer cells; viral evolution; neutralizing antibody; IMMUNODEFICIENCY-VIRUS TYPE-1; ACUTE VIREMIA; T-LYMPHOCYTE; NK CELLS; INFECTION; TRANSMISSION; RESPONSES; REVERSION; MUTATIONS; EVOLUTION;

D O I：

10.1073/pnas.1016048108

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Effective immunity to HIV is poorly understood. In particular, a role for antibody-dependent cellular cytotoxicity (ADCC) in controlling HIV is controversial. We hypothesized that significant pressure from HIV-specific ADCC would result in immune-escape variants. A series of ADCC epitopes in HIV-infected subjects to specific consensus strain HIV peptides were mapped using a flow cytometric assay for natural killer cell activation. We then compared the ADCC responses to the same peptide epitope derived from the concurrent HIV sequence(s) expressed in circulating virus. In 9 of 13 epitopes studied, ADCC antibodies were unable to recognize the concurrent HIV sequence. Our studies suggest ADCC responses apply significant immune pressure on the virus. This result has implications for the induction of ADCC responses by HIV vaccines.

引用

页码：7505 / 7510

页数：6

共 26 条

[1] Induction of HIV-1 subtype B and AE-specific neutralizing antibodies in mice and macaques with DNA prime and recombinant gp140 protein boost regimens [J].

Center, Rob J. ;

Wheatley, Adam K. ;

Campbell, Shahan M. ;

Gaeguta, Adriana J. ;

Peut, Viv ;

Alcantara, Sheilajen ;

Siebentritt, Carly ;

Kent, Stephen J. ;

Purcell, Damian F. J. .

VACCINE, 2009, 27 (47) :6605-6612

[2] The Utility of ADCC Responses in HIV Infection [J].

Chung, Amy ;

Rollman, Erik ;

Johansson, Susanne ;

Kent, Stephen J. ;

Stratov, Ivan .

CURRENT HIV RESEARCH, 2008, 6 (06) :515-519

[3] Rapid Degranulation of NK Cells following Activation by HIV-Specific Antibodies [J].

Chung, Amy W. ;

Rollman, Erik ;

Center, Rob J. ;

Kent, Stephen J. ;

Stratov, Ivan .

JOURNAL OF IMMUNOLOGY, 2009, 182 (02) :1202-1210

[4] Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype [J].

Dinges, Warren L. ;

Richardt, Julia ;

Friedrich, David ;

Jalbert, Emilie ;

Liu, Yi ;

Stevens, Claire E. ;

Maenza, Janine ;

Collier, Ann C. ;

Geraghty, Daniel E. ;

Smith, Jeremy ;

Moodie, Zoe ;

Mullins, James I. ;

McElrath, M. Juliana ;

Horton, Helen .

JOURNAL OF VIROLOGY, 2010, 84 (09) :4461-4468

[5] Vaccine-induced T cells control reversion of AIDS virus immune escape mutants [J].

Fernandez, Caroline S. ;

Smith, Miranda Z. ;

Batten, C. Jane ;

De Rose, Robert ;

Reece, Jeanette C. ;

Rollman, Erik ;

Venturi, Vanessa ;

Davenport, Miles P. ;

Kent, Stephen J. .

JOURNAL OF VIROLOGY, 2007, 81 (08) :4137-4144

[6] Rapid viral escape at an immunodominant simian-human immunodeficiency virus cytotoxic T-lymphocyte epitope exacts a dramatic fitness cost [J].

Fernandez, CS ;

Stratov, I ;

De Rose, R ;

Walsh, K ;

Dale, CJ ;

Smith, MZ ;

Agy, MB ;

Hu, SL ;

Krebs, K ;

Watkins, DI ;

O'Connor, DH ;

Davenport, MP ;

Kent, SJ .

JOURNAL OF VIROLOGY, 2005, 79 (09) :5721-5731

[7] Contribution of Nonneutralizing Vaccine-Elicited Antibody Activities to Improved Protective Efficacy in Rhesus Macaques Immunized with Tat/Env Compared with Multigenic Vaccines [J].

Florese, Ruth H. ;

Demberg, Thorsten ;

Xiao, Peng ;

Kuller, LaRene ;

Larsen, Kay ;

Summers, L. Ebonita ;

Venzon, David ;

Cafaro, Aurelio ;

Ensoli, Barbara ;

Robert-Guroff, Marjorie .

JOURNAL OF IMMUNOLOGY, 2009, 182 (06) :3718-3727

[8] Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients [J].

Goepfert, Paul A. ;

Lumm, Wendy ;

Farmer, Paul ;

Matthews, Philippa ;

Prendergast, Andrew ;

Carlson, Jonathan M. ;

Derdeyn, Cynthia A. ;

Tang, Jianming ;

Kaslow, Richard A. ;

Bansal, Anju ;

Yusim, Karina ;

Heckerman, David ;

Mulenga, Joseph ;

Allen, Susan ;

Goulder, Philip J. R. ;

Hunter, Eric .

JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (05) :1009-1017

[9] A simplified method for the rapid fluorometric assessment of antibody-dependent cell-mediated cytotoxicity [J].

Gómez-Román, VR ;

Florese, RH ;

Patterson, LJ ;

Peng, B ;

Venzon, D ;

Aldrich, K ;

Robert-Guroff, M .

JOURNAL OF IMMUNOLOGICAL METHODS, 2006, 308 (1-2) :53-67

[10] Vaccine-elicited antibodies mediate antibody-dependent cellular cytotoxicity correlated with significantly reduced acute viremia in rhesus macaques challenged with SIVmac251 [J].

Gómez-Román, VR ;

Patterson, LJ ;

Venzon, D ;

Liewehr, D ;

Aldrich, K ;

Florese, R ;

Robert-Guroff, M .

JOURNAL OF IMMUNOLOGY, 2005, 174 (04) :2185-2189

← 1 2 3 →