Cowpea mosaic virus-based systems for the production of antigens and antibodies in plants

被引：42

作者：

Liu, L ^{[1
]}

Cañizares, MC ^{[1
]}

Monger, W ^{[1
]}

Perrin, Y ^{[1
]}

Tsakiris, E ^{[1
]}

Porta, C ^{[1
]}

Shariat, N ^{[1
]}

Nicholson, L ^{[1
]}

Lomonossoff, GP ^{[1
]}

机构：

[1] John Innes Ctr Plant Sci Res, Norwich NR4 7UH, Norfolk, England

来源：

VACCINE | 2005年 / 23卷 / 15期

关键词：

cowpea mosaic virus; epitope presentation; polypeptide expression;

D O I：

10.1016/j.vaccine.2004.11.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cowpea mosaic virus (CPMV) is a bipartite RNA plant virus which has proved to be useful both for epitope presentation and as a polypeptide expression system. For epitope presentation, short antigenic sequences are expressed on the surface of the assembled virus. Chimaeric virus particles produced in this way can stimulate protective immunity in experimental animals. For polypeptide expression, we have created a vector in which foreign sequences can be inserted near the 3' end of RNA-2 and have successfully expressed a number of polypeptides in plant tissue. To extend the utility of the CPMV-based systems, we have recently developed a combined virus vector/transgenic expression system in which RNA-2 expressed from a transgene is replicated by RNA-1. (c) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1788 / 1792

页数：5

共 18 条

[1] Pseudomonas aeruginosa outer-membrane protein F epitopes are highly immunogenic in mice when expressed an a plant virus [J].

Brennan, FR ;

Jones, TD ;

Gilleland, LB ;

Bellaby, T ;

Xu, F ;

North, PC ;

Thompson, A ;

Staczek, J ;

Lin, T ;

Johnson, JE ;

Hamilton, WDO ;

Gilleland, HE .

MICROBIOLOGY-SGM, 1999, 145 :211-220

[2] A chimaeric plant virus vaccine protects mice against a bacterial infection [J].

Brennan, FR ;

Gilleland, LB ;

Staczek, J ;

Bendig, MM ;

Hamilton, WDO ;

Gilleland, HE .

MICROBIOLOGY-SGM, 1999, 145 :2061-2067

[3] Cowpea mosaic virus: From the presentation of antigenic peptides to the display of active biomaterials [J].

Chatterji, A ;

Burns, LL ;

Taylor, SS ;

Lomonossoff, GP ;

Johnson, JE ;

Lin, T ;

Porta, C .

INTERVIROLOGY, 2002, 45 (4-6) :362-370

[4] Plant-derived vaccine protects target animals against a viral disease [J].

Dalsgaard, K ;

Uttenthal, A ;

Jones, TD ;

Xu, F ;

Merryweather, A ;

Hamilton, WDO ;

Langeveld, JPM ;

Boshuizen, RS ;

Kamstrup, S ;

Lomonossoff, GP ;

Porta, C ;

Vela, C ;

Casal, JI ;

Meloen, RH ;

Rodgers, PB .

NATURE BIOTECHNOLOGY, 1997, 15 (03) :248-252

[5] Engineering cowpea mosaic virus RNA-2 into a vector to express heterologous proteins in plants [J].

Gopinath, K ;

Wellink, J ;

Porta, C ;

Taylor, KM ;

Lomonossoff, GP ;

van Kammen, A .

VIROLOGY, 2000, 267 (02) :159-173

[6] Inactivated recombinant plant virus protects dogs from a lethal challenge with canine parvovirus [J].

Langeveld, JPM ;

Brennan, FR ;

Martínez-Torrecuadrada, JL ;

Jones, TD ;

Boshuizen, RS ;

Vela, C ;

Casal, JI ;

Kamstrup, S ;

Dalsgaard, K ;

Meloen, RH ;

Bendig, MM ;

Hamilton, WDO .

VACCINE, 2001, 19 (27) :3661-3670

[7] Mammalian cell expression of dimeric small immune proteins (SIP) [J].

Li, EQ ;

Pedraza, A ;

Bestagno, M ;

Mancardi, S ;

Sanchez, R ;

Burrone, O .

PROTEIN ENGINEERING, 1997, 10 (06) :731-736

[8] The refined crystal structure of cowpea mosaic virus at 2.8 Å resolution [J].

Lin, TW ;

Chen, ZG ;

Usha, R ;

Stauffacher, CV ;

Dai, JB ;

Schmidt, T ;

Johnson, JE .

VIROLOGY, 1999, 265 (01) :20-34

[9] Structures of picorna-like plant viruses: Implications and applications [J].

Lin, TW ;

Johnson, JE .

ADVANCES IN VIRUS RESEARCH, VOL 62, 2003, 62 :167-239

[10] Cowpea mosaic virus RNA-1 acts as an amplicon whose effects can be counteracted by a RNA-2-encoded suppressor of silencing [J].

Liu, L ;

Grainger, J ;

Cañizares, MC ;

Angell, SM ;

Lomonossoff, GP .

VIROLOGY, 2004, 323 (01) :37-48

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