Superoxide anion scavenging effect of coumarins

被引：89

作者：

Chang, WS

Lin, CC

Chuang, SC

Chiang, HC

机构：

[1] School of Pharmacy, College of Medicine, National Taiwan University, Taipei, 1, Jen-ei Road

[2] Graduate Institute of Natural Products, Kaohsiung Medical College, Kaohsiung

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 1996年 / 24卷 / 01期

关键词：

D O I：

10.1142/S0192415X96000037

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

The superoxide scavenging effects of fifteen coumarins were tested on the xanthine-xanthine oxidase-cytochrome C system. The results showed that fraxetin(10) displayed the strongest activity, and its percent inhibition at 100, 10 and 1 mu M were 100, 100 and 53.13% respectively. Esculetin(4) showed the second strongest activity resulting in percent inhibition at 100 and 10 mu M were 87.16 and 52.38% respectively. Both fraxetin(10) and esculetin(4) have been isolated from the plant, Fraxinus bungeana DC (Oleaceae) which has been used in folk medicine as an analgesic and anti-inflammatory medicine. It seems that two phenolic hydroxy groups in the ortho position in the molecule of coumarins play an important role in scavenging activity.

引用

页码：11 / 17

页数：7

共 17 条

[1]

CHANG WS, 1994, ANTICANCER RES, V14, P501

[2]

CHANG WS, 1995, IN PRESS ANTICANCER, V15

[3] OXYGEN RADICALS AND HUMAN-DISEASE [J].